ArticleMammalian genome : official journal of the International Mammalian Genome Society2002
Congenic mapping of a blood pressure QTL on chromosome 16 of Dahl rats.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 21 citations in OpenAlex.
- Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans.Physiological reviews · 2017Review
- Vascular responses in aortic rings of a consomic rat panel derived from the Fawn Hooded Hypertensive strain.Physiological genomics · 2010Article
- Substitution of Brown Norway chromosome 16 preserves cardiac function with aging in a salt-sensitive Dahl consomic rat.Physiological genomics · 2008Article
- Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease.American journal of physiology. Renal physiology · 2008Article
- Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.Genome research · 2004Article
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4 authors at 2 institutions in 1 country.
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Abstract
A Chromosome (Chr) 16 segment of the Dahl salt-sensitive (S) rat was shown by linkage to contain a blood pressure (BP) quantitative trait locus (QTL). To verify and further narrow down the region harboring the QTL, we made two congenic strains by replacing two segments of the S rats with the homologous segments of the Lewis (LEW) rats. The construction of these congenic strains was facilitated by a genome-wide marker screening. The two congenic strains contained a segment in common, and BPs of both were significantly lower than that of the S strain. Consequently, a BP QTL could be localized to the overlapping region of about 49.4 centiRay (cR) including the telomere on a radiation hybrid map. Heart weights, left and right ventricular weights, kidney weights, and aortic weights over length were all significantly decreased in the congenic strains compared with the S strain. Thus, there appeared to exist an association between the effects of the QTL on BP and on cardiac, renal, and vascular hypertrophy.
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