ArticleJournal of clinical pathology2002
Expression of antimicrobial neutrophil defensins in epithelial cells of active inflammatory bowel disease mucosa.
Article in Journal of clinical pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 81 citations in OpenAlex.
- Toll-like receptors in the inflammatory response during open and laparoscopic colectomy for colorectal cancer.Surgical endoscopy · 2012Trial
- Α-defensin expression of inflammatory response in open and laparoscopic colectomy for colorectal cancer.World journal of surgery · 2011Trial
- Review
- Mechanisms of Inflammation in Post-Operative Recurrence of Crohn's Disease.Journal of inflammation research · 2026Review
- Melatonin-induced restoration of the intestinal mucosal barrier in inflammatory bowel disease via activation of the SIRT1-LKB1-pAMPK axis.Frontiers in immunology · 2026Article
- Cytokine Profile in Predicting the Effectiveness of Advanced Therapy for Ulcerative Colitis: A Narrative Review.Biomedicines · 2024Review
- Pathophysiology of Inflammatory Bowel Disease: Innate Immune System.International journal of molecular sciences · 2023Review
- Antimicrobial peptides and the gut microbiome in inflammatory bowel disease.World journal of gastroenterology · 2021Article
- Alpha-defensins (α-Defs) in Crohn's disease: decrease of ileal α-Def 5 via permanent methylation and increase in plasma α-Def 1-3 concentrations offering biomarker utility.Clinical and experimental immunology · 2018Article
- Pathobiology of neutrophil-epithelial interactions.Immunological reviews · 2016Review
- Low Mass Blood Peptides Discriminative of Inflammatory Bowel Disease (IBD) Severity: A Quantitative Proteomic Perspective.Molecular & cellular proteomics : MCP · 2016Article
- Antimicrobial proteins in intestine and inflammatory bowel diseases.Intestinal research · 2014Review
- Cellular response to Trypanosoma cruzi infection induces secretion of defensin α-1, which damages the flagellum, neutralizes trypanosome motility, and inhibits infection.Infection and immunity · 2013Article
- The role of polymorphonuclear leukocyte trafficking in the perpetuation of inflammation during inflammatory bowel disease.Inflammatory bowel diseases · 2013Review
- Antimicrobial peptides and colitis.Current pharmaceutical design · 2013Review
- Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats.Journal of nutrition and metabolism · 2012Article
- Alpha-defensin DEFA1A3 gene copy number elevation in Danish Crohn's disease patients.Digestive diseases and sciences · 2011Article
- Chronic colitis induces expression of β-defensins in murine intestinal epithelial cells.Clinical and experimental immunology · 2011Article
- Article
- MDP-NOD2 stimulation induces HNP-1 secretion, which contributes to NOD2 antibacterial function.Inflammatory bowel diseases · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsThe normal intestinal epithelium is increasingly being recognised as an important component of the mucosal innate protection against microorganisms. Human neutrophil defensins 1-3 (HNP 1-3) and lysozyme are components of the systemic innate immunity. The aim of this study was to investigate the expression of HNP 1-3 and lysozyme in normal and active inflammatory bowel disease (IBD) mucosa.
methodsMucosal tissue sections were studied by immunohistochemistry using antibodies to neutrophil defensins 1-3 and lysozyme. Extracts of purified intestinal epithelial cells were used for immunoblotting studies and antimicrobial activity against the phoP negative strain of Salmonella typhimurium.
resultsSurface epithelial cells strongly immunoreactive for neutrophil defensins and lysozyme were seen in active ulcerative colitis and Crohn's disease (but not normal or inactive IBD) mucosal samples. Many of these cells coexpressed both of the antimicrobial proteins. Immunoblotting studies confirmed the expression of neutrophil defensins in extracts of purified ulcerative colitis epithelial cells, which also demonstrated antimicrobial activity.
conclusionHNP 1-3 and lysozyme are expressed in surface enterocytes of mucosa with active IBD and they may play an important role in intestinal host defence against luminal microorganisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.