Evidence map›Paper›PMID 11919208›Full record

ReviewJournal of clinical pathology2002

The causal relation between human papillomavirus and cervical cancer.

F X Bosch, A Lorincz, N Muñoz, C J L M Meijer, K V Shah

5 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Journal of clinical pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 1,098 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,098citing papers in PubMed, 8 pooled it
78.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01021904 phase4unknown statusnot on this mapstarted 2010, after this paper: background citation

Primary and Secondary Prevention of Human Papillomavirus (HPV) Disease in China

TypeinterventionalSponsorChinese Academy of Medical SciencesRan2010 to 2014Enrolled6,200ConditionsHPV Infections, Precancerous Disease of the Cervix, Cervical Cancer, HPV Related DiseasesArmsGardasil (VLP, HPV Quadrivalent prophylactic vaccine)
NCT04624568 nacompletednot on this mapstarted 2020, after this paper: background citation

Papilocare®: Effects on Regression of Histologically Confirmed Cervical Intraepithelial Lesions 1 and Tolerance.

TypeinterventionalSponsorCentre Hospitalier Régional d'OrléansRan2020 to 2023Enrolled81ConditionsSquamous Intraepithelial Lesions of the Cervix, Human Papilloma Virus Infection, Cervix LesionArmsPAPILOCARE
NCT05210348 unknown statusnot on this mapstarted 2021, after this paper: background citation

Clinical Evaluation Study of Urine hrHPV Detection for the Diagnosis of Presence of Cervical HPV and Correlation of Cervical Lesions

TypeobservationalSponsorPeking University People's HospitalRan2021 to 2022Enrolled1,000ConditionsHuman Papillomavirus Infection, Cervical Cancer, Human Papilloma Virus, Negative for Intraepithelial Lesion or Malignancy
NCT06536855 phase4unknown statusnot on this mapstarted 2024, after this paper: background citation

Faster Elimination of HPV Infection and Cervical Cancer Using Concomitant HPV Vaccination and HPV Screening: A Demonstration Project in Rwanda

TypeinterventionalSponsorRwanda Biomedical CentreRan2024 to 2026Enrolled100,000ConditionsCervical CancerArmsGardasil 9
NCT07435623 recruitingnot on this mapstarted 2025, after this paper: background citation

Assessment of Late Gastrointestinal and Genitourinary Toxicities in Cervical and Endometrial Cancer Requiring Postoperative IMRT and/or Brachytherapy

TypeobservationalSponsorTata Memorial HospitalRan2025 to 2026Enrolled300ConditionsEndometrial Cancer, Cervix Cancer
3 · Its place in the literature

Who cites it

1,098 citing papers in PubMed, 8 syntheses or guidelines pooled it, 3,559 citations in OpenAlex.

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1,038 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

F X BoschInstitut Català d'Oncologia, Servei d'Epidemiologia i Registre del Càncer, Gran Via Km 2.7 s/n 08907 L'Hospitalet de Llobregat, 08907 Barcelona, Spain. x.bosch@ico.scs.es
A Lorincz
N Muñoz
C J L M Meijer
K V Shah
Centre international de recherche sur le cancer · FRInstitut Català d'Oncologia · ESJohns Hopkins University · USVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The causal role of human papillomavirus infections in cervical cancer has been documented beyond reasonable doubt. The association is present in virtually all cervical cancer cases worldwide. It is the right time for medical societies and public health regulators to consider this evidence and to define its preventive and clinical implications. A comprehensive review of key studies and results is presented.

Indexed as

CausalityCell Transformation, NeoplasticCell Transformation, ViralDNA, ViralFemaleHumansPapillomaviridaePapillomavirus InfectionsRisk FactorsTumor Virus InfectionsUterine Cervical NeoplasmsDNA, Viral

Identifiers

PMID11919208
PMCPMC1769629
OpenAlexW2114813165

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.