ArticleArchives of disease in childhood2002
Cough, airway inflammation, and mild asthma exacerbation.
Article in Archives of disease in childhood, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 46 citations in OpenAlex.
- Epidemiological characteristics of adenovirus in children in Yancheng, China, 2023-2024.Frontiers in cellular and infection microbiology · 2025Article
- A smartphone-based application for cough counting in patients with acute asthma exacerbation.Journal of thoracic disease · 2023Article
- Cough Hypersensitivity Syndrome: Why Its Use Is Inappropriate in Children.Journal of clinical medicine · 2023Article
- Upper Respiratory Tract Infection-Associated Acute Cough and the Urge to Cough: New Insights for Clinical Practice.Pediatric allergy, immunology, and pulmonology · 2020Review
- Feasibility of a Peer-Led Asthma and Smoking Prevention Project in Australian Schools with High Indigenous Youth.Frontiers in pediatrics · 2017Article
- Types, frequency and impact of asthma triggers on patients' lives: a quantitative study in five European countries.The Journal of asthma : official journal of the Association for the Care of Asthma · 2014Article
- An observational study on cough in children: epidemiology, impact on quality of sleep and treatment outcome.Cough (London, England) · 2012Article
- Article
- Cough: are children really different to adults?Cough (London, England) · 2005Article
- Article
- Relation between measurements of cough severity.Archives of disease in childhood · 2003Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProspective data on the temporal relation between cough, asthma symptoms, and airway inflammation in childhood asthma is unavailable. AIMS AND
methodsUsing several clinical (diary, quality of life), lung function (FEV(1), FEV(1) variability, airway hyperresponsiveness), cough (diary, cough receptor sensitivity (CRS)), and inflammatory markers (sputum interleukin 8, eosinophilic cationic protein (ECP), myeloperoxidase; and serum ECP) of asthma severity, we prospectively described the course of these markers in children with asthma during a non-acute, acute, and resolution phase. A total of 21 children with asthma underwent these baseline tests; 11 were retested during days 1, 3, 7, and 28 of an exacerbation.
resultsAsthma exacerbations were characterised by increased asthma and cough symptoms and eosinophilic inflammation. Sputum ECP showed the largest increase and peaked later than clinical scores. Asthma scores consistently related to cough score only early in the exacerbation. Neither CRS nor cough scores related to any inflammatory marker.
conclusionIn mild asthma exacerbations, eosinophilic inflammation is dominant. In asthmatic children who cough as a dominant symptom, cough heralds the onset of an exacerbation and increased eosinophilic inflammation, but cough scores and CRS do not reflect eosinophilic airway inflammation.
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