ArticleClinical & experimental metastasis2002
Monocyte chemoattractant protein-1 (MCP-1), secreted by bone marrow endothelial cells, induces chemoattraction of 5T multiple myeloma cells.
Article in Clinical & experimental metastasis, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Review
- Tumour Dissemination in Multiple Myeloma Disease Progression and Relapse: A Potential Therapeutic Target in High-Risk Myeloma.Cancers · 2020Review
- Tissue Factor-Expressing Tumor-Derived Extracellular Vesicles Activate Quiescent Endothelial CellsFrontiers in oncology · 2017Article
- Smac Mimetic-Induced Upregulation of CCL2/MCP-1 Triggers Migration and Invasion of Glioblastoma Cells and Influences the Tumor Microenvironment in a Paracrine Manner.Neoplasia (New York, N.Y.) · 2015Article
- Article
- Mouse models as a translational platform for the development of new therapeutic agents in multiple myeloma.Current cancer drug targets · 2012Review
- Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy.Journal of neuro-oncology · 2011Article
- Article
- Macrophage chemotactic protein-1 mRNA levels in non-Hodgkin lymphoma.Clinical and experimental medicine · 2010Article
- Multiple roles of chemokine (C-C motif) ligand 2 in promoting prostate cancer growth.Journal of the National Cancer Institute · 2010Review
- CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis.Cytokine & growth factor reviews · 2010Review
- Targeting chemokine (C-C motif) ligand 2 (CCL2) as an example of translation of cancer molecular biology to the clinic.Progress in molecular biology and translational science · 2010Review
- Synergy between anti-CCL2 and docetaxel as determined by DW-MRI in a metastatic bone cancer model.Journal of cellular biochemistry · 2009Article
- CCL2 protects prostate cancer PC3 cells from autophagic death via phosphatidylinositol 3-kinase/AKT-dependent survivin up-regulation.The Journal of biological chemistry · 2008Article
- Stepping out of the flow: capillary extravasation in cancer metastasis.Clinical & experimental metastasis · 2008Review
- CCL2 as an important mediator of prostate cancer growth in vivo through the regulation of macrophage infiltration.Neoplasia (New York, N.Y.) · 2007Article
- CCL2 is a potent regulator of prostate cancer cell migration and proliferation.Neoplasia (New York, N.Y.) · 2006Article
- Article
- Part of the multiple myeloma-associated microvessels is functionally connected to the systemic circulation: a study in the murine 5T33MM model.Virchows Archiv : an international journal of pathology · 2004Article
- Chemokines, chemokine receptors and adhesion molecules on different human endothelia: discriminating the tissue-specific functions that affect leucocyte migration.Clinical and experimental immunology · 2003Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homing of multiple myeloma (MM) cells to the bone marrow (BM) requires transendothelial migration. In the present work we tested whether monocyte chemoattractant protein-1 (MCP-1) and CCR2, the high affinity receptor for MCP-1, are involved in this process. Murine 5T2 and 5T33MM cell lines were selected as source of MM cells and STR4, 10 and 12 of BM endothelial cells (BMEC). RT-PCR demonstrated transcripts for MCP-1 in BMEC and ELISA the presence of MCP-1 protein in culture medium. RNase protection assay showed mRNA expression for CCR2, and FACS analysis the presence of CCR2 protein on the MM cells. EC conditioned medium induced chemoattraction of MM cells, a phenomenon inhibited by anti-MCP-1 antibodies. In conclusion, MM cells express CCR2 and are attracted by MCP-1 secreted by BMEC. We suggest that local MCP-1 production by BMEC is one of the mechanisms involved in homing of myeloma cells to the BM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.