ArticleBiophysical journal2002
Ca2+-activated K+ currents regulate odor adaptation by modulating spike encoding of olfactory receptor cells.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Immature olfactory sensory neurons are intrinsically excitable and show maturation-dependent changes in voltage-gated NaPflugers Archiv : European journal of physiology · 2026Article
- Quantifying Peripheral Modulation of Olfaction by Trigeminal Agonists.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- KBiomedicines · 2023Review
- A Comparison of the Primary Sensory Neurons Used in Olfaction and Vision.Frontiers in cellular neuroscience · 2020Review
- Adaptive integrate-and-fire model reproduces the dynamics of olfactory receptor neuron responses in a moth.Journal of the Royal Society, Interface · 2019Article
- Moth olfactory receptor neurons adjust their encoding efficiency to temporal statistics of pheromone fluctuations.PLoS computational biology · 2018Article
- Hyperpolarisation-activated cyclic nucleotide-gated channels regulate the spontaneous firing rate of olfactory receptor neurons and affect glomerular formation in mice.The Journal of physiology · 2013Article
- Computational modelling elucidates the mechanism of ciliary regulation in health and disease.BMC systems biology · 2011Article
- Urine stimulation activates BK channels in mouse vomeronasal neurons.Journal of neurophysiology · 2008Article
- The BK-mediated fAHP is modulated by learning a hippocampus-dependent task.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Characteristic component odors emerge from mixtures after selective adaptation.Brain research bulletin · 2007Article
- Activation of purinergic receptor subtypes modulates odor sensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Tonic and phasic receptor neurons in the vertebrate olfactory epithelium.Biophysical journal · 2003Article
- Slow Na+ inactivation and variance adaptation in salamander retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The olfactory system is thought to accomplish odor adaptation through the ciliary transduction machinery in olfactory receptor cells (ORCs). However, ORCs that have lost their cilia can exhibit spike frequency accommodation in which the action potential frequency decreases with time despite a steady depolarizing stimulus. This raises the possibility that somatic ionic channels in ORCs might serve for odor adaptation at the level of spike encoding, because spiking responses in ORCs encode the odor information. Here I investigate the adaptational mechanism at the somatic membrane using conventional and dynamic patch-clamp recording techniques, which enable the ciliary mechanism to be bypassed. A conditioning stimulus with an odorant-induced current markedly shifted the response range of action potentials induced by the same test stimulus to higher concentrations of the odorant, indicating odor adaptation. This effect was inhibited by charybdotoxin and iberiotoxin, Ca2+-activated K+ channel blockers, suggesting that somatic Ca2+-activated K+ currents regulate odor adaptation by modulating spike encoding. I conclude that not only the ciliary machinery but also the somatic membrane currents are crucial to odor adaptation.
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