ArticleJournal of bacteriology2002
Role for vitamin B(12) in light induction of gene expression in the bacterium Myxococcus xanthus.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Establishing conserved biosynthetic gene clusters of the phylum Myxococcota.Applied and environmental microbiology · 2026Article
- Redox driven BNature communications · 2023Article
- Assessment of Evolutionary Relationships for Prioritization of Myxobacteria for Natural Product Discovery.Microorganisms · 2021Article
- Light-Triggered Carotenogenesis inMicroorganisms · 2021Review
- 2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene-Nucleoside.Molecules (Basel, Switzerland) · 2020Article
- Survey of Biosynthetic Gene Clusters from Sequenced Myxobacteria Reveals Unexplored Biosynthetic Potential.Microorganisms · 2019Article
- Mutation analysis of genes related to methylmalonic acidemia: identification of eight novel mutations.Molecular biology reports · 2019Article
- A New Facet of Vitamin BAnnual review of biochemistry · 2017Review
- The photochemical mechanism of a B12-dependent photoreceptor protein.Nature communications · 2015Article
- Role and Function of LitR, an Adenosyl B12-Bound Light-Sensitive Regulator of Bacillus megaterium QM B1551, in Regulation of Carotenoid Production.Journal of bacteriology · 2015Article
- Analytical ultracentrifugation studies of oligomerization and DNA-binding of TtCarH, a Thermus thermophilus coenzyme B12-based photosensory regulator.European biophysics journal : EBJ · 2013Article
- Light-dependent gene regulation by a coenzyme B12-based photoreceptor.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Genetic control for light-induced carotenoid production in non-phototrophic bacteria.Journal of industrial microbiology & biotechnology · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A light-inducible promoter (P(B)) drives the carB operon (carotenoid genes) of the bacterium Myxococcus xanthus. A gene encoding a regulator of carotenoid biosynthesis was identified by studying mutant strains carrying a transcriptional fusion to P(B) and deletions in three candidate genes. Our results prove that the identified gene, named carA, codes for a repressor of the P(B) promoter in the dark. They also show that the carA gene product does not participate in the light activation of two other promoters connected with carotenoid synthesis or its regulation in M. xanthus. CarA is a novel protein consisting of a DNA-binding domain of the family of MerR helix-turn-helix transcriptional regulators, directly joined to a cobalamin-binding domain. In support of this, we report here that the presence of vitamin B(12) or some other cobalamin derivatives is absolutely required for activation of the P(B) promoter by light.
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