ArticleJournal of bacteriology2002
Population genetic structure of Legionella pneumophila inferred from RNA polymerase gene (rpoB) and DotA gene (dotA) sequences.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Longitudinal Antimicrobial Susceptibility Shifts in EnvironmentalPathogens (Basel, Switzerland) · 2026Article
- New Insight regardingMicrobiology spectrum · 2021Article
- Comparative genome analysis reveals a complex population structure of Legionella pneumophila subspecies.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Article
- Environmental surveillance and molecular epidemiology of waterborne pathogen Legionella pneumophila in health-care facilities of Northeastern Greece: a 4-year survey.Environmental science and pollution research international · 2015Article
- Intragenic recombination has a critical role on the evolution of Legionella pneumophila virulence-related effector sidJ.PloS one · 2014Article
- Extensive recombination events and horizontal gene transfer shaped the Legionella pneumophila genomes.BMC genomics · 2011Article
- The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever.PLoS genetics · 2007Article
- Catheter-associated bacteremia by Mycobacterium senegalense in Korea.BMC infectious diseases · 2005Article
- Quantitative detection of Legionella pneumophila in water samples by immunomagnetic purification and real-time PCR amplification of the dotA gene.Applied and environmental microbiology · 2005Article
- Introducing DOTUR, a computer program for defining operational taxonomic units and estimating species richness.Applied and environmental microbiology · 2005Article
- Presence and persistence of Legionella spp. in groundwater.Applied and environmental microbiology · 2005Article
- Clinical and environmental isolates of Legionella pneumophila serogroup 1 cannot be distinguished by sequence analysis of two surface protein genes and three housekeeping genes.Applied and environmental microbiology · 2005Article
- Population structure of the Bacillus cereus group as determined by sequence analysis of six housekeeping genes and the plcR Gene.Infection and immunity · 2004Article
- Alanine-threonine polymorphism of Helicobacter pylori RpoB is correlated with differential induction of interleukin-8 in MKN45 cells.Journal of clinical microbiology · 2004Article
- Molecular evolution of the dotA gene in Legionella pneumophila.Journal of bacteriology · 2003Article
- Gamma-proteobacteria Aquicella lusitana gen. nov., sp. nov., and Aquicella siphonis sp. nov. infect protozoa and require activated charcoal for growth in laboratory media.Applied and environmental microbiology · 2003Article
- A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophila.Journal of bacteriology · 2003Article
- Mosaic structure of pathogenicity islands in Legionella pneumophila.Journal of molecular evolution · 2003Article
- Characterization of a tandem repeat polymorphism in Legionella pneumophila and its use for genotyping.Journal of clinical microbiology · 2003Article
- Application of RNA polymerase beta-subunit gene (rpoB) sequences for the molecular differentiation of Legionella species.Journal of clinical microbiology · 2002Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The population structure of Legionella pneumophila was studied by using partial RNA polymerase gene (rpoB) and DotA gene (dotA) sequences. Trees inferred from rpoB sequences showed that two subspecies of L. pneumophila, Legionella pneumophila subsp. pneumophila and Legionella pneumophila subsp. fraseri, were clearly separated genetically. In both rpoB and dotA trees, 79 Korean isolates used in this study constituted six clonal populations, four of which (designated subgroups P-I to P-IV) were identified in L. pneumophila subsp. pneumophila and two of which (designated subgroups F-I and F-II) were identified in L. pneumophila subsp. fraseri. Although the relationships among subgroups were not identical, such subgrouping was congruent between the rpoB and dotA trees. Type strains of several serogroups did not belong to any subgroup, presumably because isolates similar to these strains were not present among our local sample of the population. There was evidence that horizontal gene transfer or recombination had occurred within L. pneumophila. Contrary to the phylogeny from rpoB and the taxonomic context, subgroups P-III and P-IV of L. pneumophila subsp. pneumophila proved to be closely related to those of L. pneumophila subsp. fraseri or showed a distinct clustering in the dotA tree. It can be inferred that dotA of subgroups P-III and P-IV has been transferred horizontally from other subspecies. The diverse distribution of serogroup 1 strains through the gene trees suggests that surface antigen-coding genes that determine serogroup can be exchanged. Thus, it can be inferred that genetic recombination has been important in the evolution of L. pneumophila.
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