ArticleBMC developmental biology2002
Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2.
Article in BMC developmental biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 60 citations in OpenAlex.
- Biophysical characterisation of the novel zinc binding property in Suppressor of Fused.Scientific reports · 2017Article
- Microtubule Motors Drive Hedgehog Signaling in Primary Cilia.Trends in cell biology · 2017Review
- Article
- CYK4 promotes antiparallel microtubule bundling by optimizing MKLP1 neck conformation.PLoS biology · 2015Article
- Contributions of Costal 2-Fused interactions to Hedgehog signaling in Drosophila.Development (Cambridge, England) · 2015Article
- A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response.PloS one · 2015Article
- Transcriptional regulation of graded Hedgehog signaling.Seminars in cell & developmental biology · 2014Review
- Hedgehog signaling downregulates suppressor of fused through the HIB/SPOP-Crn axis in Drosophila.Cell research · 2014Article
- Extramacrochaetae imposes order on the Drosophila eye by refining the activity of the Hedgehog signaling gradient.Development (Cambridge, England) · 2013Article
- The Hedgehog signal transduction network.Science signaling · 2012Review
- Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses.Developmental cell · 2011Article
- KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes.Nature genetics · 2011Article
- Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation.Development (Cambridge, England) · 2011Article
- Costal 2 interactions with Cubitus interruptus (Ci) underlying Hedgehog-regulated Ci processing.Developmental biology · 2010Article
- Non-cell-autonomous signaling by Shh in tumors: challenges and opportunities for therapeutic targets.Expert opinion on therapeutic targets · 2010Review
- Article
- Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway.Current biology : CB · 2008Article
- The role of kinases in the Hedgehog signalling pathway.EMBO reports · 2008Review
- Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation.Genes & development · 2007Article
- Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development.Molecular and cellular biology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundHedgehog signaling proteins play important roles in development by controlling growth and patterning in various animals including Drosophila and mammals. Hedgehog signaling triggers changes in responsive cells through a novel transduction mechanism that ultimately controls the transcription of specific target genes via the activity of zinc finger transcription factors of the Cubitus interruptus/GLI family. In flies, key Hedgehog signal transduction components have been identified including the kinesin-related protein Costal2, the serinethreonine kinase Fused, and the PEST-containing protein Suppressor of Fused. These proteins control Cubitus interruptus cleavage, nucleo-cytoplasmic localization and activation. In fly embryos, Costal2, Fused, Suppressor of Fused and Cubitus interruptus are associated in at least one cytoplasmic complex, which interacts with the microtubules in a Hedgehog-dependent manner.
resultsHere we identified and mapped direct interactions between Cos2, Fu, and Ci using an in vitro affinity assay and the yeast two-hybrid system.
conclusionsOur results provide new insights into the possible mechanism of the cytosolic steps of Hedgehog transduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.