ArticleMycopathologia2002
Association of aflatoxin biosynthesis and sclerotial development in Aspergillus parasiticus.
Article in Mycopathologia, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- Mutations and Metabolic Factors Affecting Interaction of Toxigenic and AtoxigenicMicroorganisms · 2026Article
- Host-Induced Gene Silencing of theToxins · 2024Article
- TheJournal of fungi (Basel, Switzerland) · 2024Article
- Biosynthesis of Sesquiterpenes in Basidiomycetes: A Review.Journal of fungi (Basel, Switzerland) · 2022Review
- SfgA RendersJournal of fungi (Basel, Switzerland) · 2022Article
- Aspergillus Section Flavi from Four Agricultural Products and Association of Mycotoxin and Sclerotia Production with Isolation Source.Current microbiology · 2021Article
- Transcriptome Dynamics Underlying Chlamydospore Formation inFrontiers in microbiology · 2021Article
- Occurrence and toxigenic potential ofMycology · 2020Article
- Aflatoxins: Producing-Molds, Structure, Health Issues and Incidence in Southeast Asian and Sub-Saharan African Countries.International journal of environmental research and public health · 2020Review
- Article
- Functional Analysis of the Nitrogen Metabolite Repression Regulator GeneFrontiers in microbiology · 2016Article
- Association of fungal secondary metabolism and sclerotial biology.Frontiers in microbiology · 2015Review
- Article
- Deletion of the Aspergillus flavus orthologue of A. nidulans fluG reduces conidiation and promotes production of sclerotia but does not abolish aflatoxin biosynthesis.Applied and environmental microbiology · 2012Article
- Current understanding on aflatoxin biosynthesis and future perspective in reducing aflatoxin contamination.Toxins · 2012Review
- An insight into the distribution, genetic diversity, and mycotoxin production of Aspergillus section Flavi in soils of pistachio orchards.Folia microbiologica · 2012Article
- A survey on distribution and toxigenicity of Aspergillus flavus from indoor and outdoor hospital environments.Folia microbiologica · 2011Article
- Regulation of secondary metabolism by chromatin structure and epigenetic codes.Fungal genetics and biology : FG & B · 2011Review
- Requirement of LaeA for secondary metabolism and sclerotial production in Aspergillus flavus.Fungal genetics and biology : FG & B · 2008Article
- Modulation of antioxidant defense in Aspergillus parasiticus is involved in aflatoxin biosynthesis: a role for the ApyapA gene.Eukaryotic cell · 2008Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secondary metabolism in fungi is frequently associated with asexual and sexual development. Aspergillus parasiticus produces aflatoxins known to contaminate a variety of agricultural commodities. This strictly mitotic fungus. besides producing conidia asexually, produces sclerotia, structures resistant to harsh conditions and for propagation. Sclerotia are considered to be derived from the sexual structure, cleistothecia. and may represent a vestige of ascospore production. Introduction of the aflatoxin pathway-specific regulatory gene, aflR, and aflJ, which encoded a putative co-activator, into an O-methylsterigmatocystin (OMST)-accumulating strain, A. parasiticus SRRC 2043, resulted in elevated levels of accumulation of major aflatoxin precursors, including norsolorinic acid (NOR), averantin (AVN), versicolorin A (VERA) and OMST. The total amount of these aflatoxin precursors, NOR, VERA, AVN and OMST, produced by the aflR plus aflJ transformants was two to three-fold that produced by the aflR transformants. This increase indicated a synergistic effect of aflR and aflJ on the synthesis of aflatoxin precursors. Increased production of the aflatoxin precursors was associated with progressive decrease in sclerotial size, alteration in sclerotial shape and weakening in the sclerotial structure of the transformants. The results showed that sclerotial development and aflatoxin biosynthesis are closely related. We proposed that competition for a common substrate, such as acetate, by the aflatoxin biosynthetic pathway could adversely affect sclerotial development in A. parasiticus.
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Registered trials
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