ReviewAlcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism2001
Effects of alcohol use and estrogen on bone.
Review in Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Article
- Ethanol alters the relationship between IGF-1 and bone turnover in male macaques.The Journal of endocrinology · 2022Article
- Patient-reported outcome measures following surgeries in implant dentistry and associated factors: a cross-sectional study.BMJ open · 2022Article
- Making Sense of the Highly Variable Effects of Alcohol on Bone.Clinical reviews in bone and mineral metabolism · 2021Article
- Effects of Chronic Ethanol Consumption and Ovariectomy on the Spontaneous Alveolar Bone Loss in Rats.International journal of dentistry · 2020Article
- Effects of Alcohol and Estrogen Receptor Blockade Using ICI 182,780 on Bone in Ovariectomized Rats.Alcoholism, clinical and experimental research · 2019Article
- Alcohol intake, specific alcoholic beverages, and risk of hip fractures in postmenopausal women and men age 50 and older.The American journal of clinical nutrition · 2019Article
- Cellular and molecular mechanisms of alcohol-induced osteopenia.Cellular and molecular life sciences : CMLS · 2017Review
- Does Oxidative Stress Induced by Alcohol Consumption Affect Orthodontic Treatment Outcome?Frontiers in physiology · 2017Review
- Alcohol: A Simple Nutrient with Complex Actions on Bone in the Adult Skeleton.Alcoholism, clinical and experimental research · 2016Review
- Article
- Intraperitoneal injection of ethanol results in drastic changes in bone metabolism not observed when ethanol is administered by oral gavage.Alcoholism, clinical and experimental research · 2013Article
- Article
- The effects of physical activity on the epiphyseal growth plates: a review of the literature on normal physiology and clinical implications.Journal of clinical medicine research · 2011Article
- Depression, selective serotonin reuptake inhibitors, and osteoporosis.Current osteoporosis reports · 2010Review
- Alcohol alters whole body composition, inhibits bone formation, and increases bone marrow adiposity in rats.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2009Article
- Effects of beer, wine, and liquor intakes on bone mineral density in older men and women.The American journal of clinical nutrition · 2009Article
- The pathophysiology of osteoporotic hip fracture.McGill journal of medicine : MJM : an international forum for the advancement of medical sciences by students · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
In marked contrast with men who drink, women who drink alcohol are found, as a group, to have higher bone mass compared with women who abstain. Furthermore, the apparent beneficial effects of alcohol use are more apparent in postmenopausal women than women of reproductive age, suggesting that there might be an interaction between alcohol and estrogen. Estrogen deficiency accompanying menopause leads to bone loss, which in turn predisposes women to osteoporosis later in life. Estrogen deficiency accelerates bone remodeling, which is the process by which small areas of bone are destroyed and rebuilt, and leads to an imbalance whereby bone resorption--the part of remodeling consisting of breaking down and assimilating--exceeds bone formation. Alcohol might reduce bone loss in postmenopausal women by increasing the circulating levels of estrogen. Alternatively, alcohol might slow bone loss by acting on bone cells to reduce bone remodeling. Alcohol use has a negative effect on the immature skeleton but current understanding suggests that small quantities of alcohol may have beneficial effects on bone in older women.
Indexed as
Identifiers
11910705PMC6705709What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.