ArticleThe Plant cell2002
The Arabidopsis salt overly sensitive 4 mutants uncover a critical role for vitamin B6 in plant salt tolerance.
Article in The Plant cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed, 206 citations in OpenAlex.
- Proteomic analysis may explain differences inPlant signaling & behavior · 2026Article
- Analysis of salt resistance conferred by salt overly sensitive 3 protein from mulberry (Frontiers in plant science · 2026Article
- Integrating multiomic resources and gene expression studies to identify candidates for engineering climate-resilientFrontiers in plant science · 2026Review
- A multi-locus genome-wide association study uncovers candidate genes for alkali tolerance in maize (Zea Mays L.) seedlings.BMC genomics · 2025Article
- Dual-omics analysis reveals B vitamin regulation and metabolism in Areca Catechu inflorescence.BMC genomics · 2025Article
- In Silico identification and characterization of SOS gene family in soybean: Potential of calcium in salinity stress mitigation.PloS one · 2025Article
- Two pyridoxal phosphate homeostasis proteins are essential for management of the coenzyme pyridoxal 5'-phosphate in Arabidopsis.The Plant cell · 2024Article
- Response Mechanisms ofInternational journal of molecular sciences · 2024Article
- PYRIDOX(AM)INE 5'-PHOSPHATE OXIDASE3 of Arabidopsis thaliana maintains carbon/nitrogen balance in distinct environmental conditions.Plant physiology · 2023Article
- Phosphorylated B6 vitamer deficiency in SALT OVERLY SENSITIVE 4 mutants compromises shoot and root development.Plant physiology · 2022Article
- Genome-wide analysis reveals the spatiotemporal expression patterns of SOS3 genes in the maize B73 genome in response to salt stress.BMC genomics · 2022Article
- Metabolomic Profiles of the Creeping Wood SorrelLife (Basel, Switzerland) · 2022Article
- One Hundred Candidate Genes and Their Roles in Drought and Salt Tolerance in Wheat.International journal of molecular sciences · 2021Review
- Identification of genetic variation for salt tolerance in Brassica napus using genome-wide association mapping.Molecular genetics and genomics : MGG · 2021Article
- Genomic Analysis ofFrontiers in microbiology · 2021Article
- Differential Defense Responses of Upland and Lowland Switchgrass Cultivars to a Cereal Aphid Pest.International journal of molecular sciences · 2020Article
- Salt Stress-Induced Structural Changes Are Mitigated in Transgenic Tomato Plants Over-Expressing Superoxide Dismutase.Biology · 2020Article
- Alfalfa MsCBL4 enhances calcium metabolism but not sodium transport in transgenic tobacco under salt and saline-alkali stress.Plant cell reports · 2020Article
- Integrative Transcriptomic and Proteomic Analyses of Molecular Mechanism Responding to Salt Stress during Seed Germination in Hulless Barley.International journal of molecular sciences · 2020Article
- Rice plastidial NAD-dependent malate dehydrogenase 1 negatively regulates salt stress response by reducing the vitamin B6 content.Plant biotechnology journal · 2020Article
10 more citing papers are in PubMed but not listed here.
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5 authors at 1 institution in 1 country.
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Abstract
Salt stress is a major environmental factor influencing plant growth and development. To identify salt tolerance determinants, a genetic screen for salt overly sensitive (sos) mutants was performed in Arabidopsis. We present here the characterization of sos4 mutants and the positional cloning of the SOS4 gene. sos4 mutant plants are hypersensitive to Na(+), K(+), and Li(+) ions. Under NaCl stress, sos4 plants accumulate more Na(+) and retain less K(+) compared with wild-type plants. SOS4 encodes a pyridoxal kinase that is involved in the biosynthesis of pyridoxal-5-phosphate, an active form of vitamin B6. The expression of SOS4 cDNAs complements an Escherichia coli mutant defective in pyridoxal kinase. Supplementation of pyridoxine but not pyridoxal in the growth medium can partially rescue the sos4 defect in salt tolerance. SOS4 is expressed ubiquitously in all plant tissues. As a result of alternative splicing, two transcripts are derived from the SOS4 gene, the relative abundance of which is modulated by development and environmental stresses. Besides being essential cofactors for numerous enzymes, as shown by pharmacological studies in animal cells, pyridoxal-5-phosphate and its derivatives are also ligands for P2X receptor ion channels. Our results demonstrate that pyridoxal kinase is a novel salt tolerance determinant important for the regulation of Na(+) and K(+) homeostasis in plants. We propose that pyridoxal-5-phosphate regulates Na(+) and K(+) homeostasis by modulating the activities of ion transporters.
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