ArticleMolecular and cellular biology2002
Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 136 citations in OpenAlex.
- Vitamin D deficiency in chronic hepatitis B across the disease spectrum: association with viral activity rather than hepatocellular carcinoma.BMC gastroenterology · 2026Article
- Article
- Intramammary 25-hydroxyvitamin DJDS communications · 2023Article
- Subcutaneous fat necrosis in newborns: a systematic literature review of case reports and model of pathophysiology.Molecular and cellular pediatrics · 2022Review
- Review
- Regulation of innate immune responses in macrophages differentiated in the presence of vitamin D and infected with dengue virus 2.PLoS neglected tropical diseases · 2021Article
- Vitamin D's Effect on Immune Function.Nutrients · 2020Review
- Synergistic Effects of Interferon-γ and Vitamin DFrontiers in immunology · 2019Article
- A curious case of growth failure and hypercalcemia: Answers.Pediatric nephrology (Berlin, Germany) · 2018Article
- Causes and consequences of genomic instability in laminopathies: Replication stress and interferon response.Nucleus (Austin, Tex.) · 2018Review
- Genomic Effects of the Vitamin D Receptor: Potentially the Link between Vitamin D, Immune Cells, and Multiple Sclerosis.Frontiers in immunology · 2018Review
- Vitamin D decreases STAT phosphorylation and inflammatory cytokine output in T-LGL leukemia.Cancer biology & therapy · 2017Article
- Vitamin D Receptor Gene Polymorphisms Influence T1D Susceptibility among Pakistanis.International journal of genomics · 2017Article
- Meta-analysis of host response networks identifies aNPJ systems biology and applications · 2017Article
- Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment.Endocrine reviews · 2016Review
- Extraskeletal actions of vitamin D.Annals of the New York Academy of Sciences · 2016Review
- The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus.Nutrients · 2016Review
- The hypercalcaemia of CYP24A1 inactivation: new ways to improve diagnosis and treatment.Clinical kidney journal · 2015Article
- Anti-inflammatory effect of 1,25-dihydroxyvitamin DExperimental and therapeutic medicine · 2015Article
- Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The cytokine gamma interferon (IFN-gamma) and the calcitropic steroid hormone 1,25-dihydroxyvitamin D (1,25D) are activators of macrophage immune function. In sarcoidosis, tuberculosis, and several granulomatoses, IFN-gamma induces 1,25D synthesis by macrophages and inhibits 1,25D induction of 24-hydroxylase, a key enzyme in 1,25D inactivation, causing high levels of 1,25D in serum and hypercalcemia. This study delineates IFN-gamma-1,25D cross talk in human monocytes-macrophages. Nuclear accumulation of Stat1 and vitamin D receptor (VDR) by IFN-gamma and 1,25D promotes protein-protein interactions between Stat1 and the DNA binding domain of the VDR. This prevents VDR-retinoid X receptor (RXR) binding to the vitamin D-responsive element, thus diverting the VDR from its normal genomic target on the 24-hydroxylase promoter and antagonizing 1,25D-VDR transactivation of this gene. In contrast, 1,25D enhances IFN-gamma action. Stat1-VDR interactions, by preventing Stat1 deactivation by tyrosine dephosphorylation, cooperate with IFN-gamma/Stat1-induced transcription. This novel 1,25D-IFN-gamma cross talk explains the pathogenesis of abnormal 1,25D homeostasis in granulomatous processes and provides new insights into 1,25D immunomodulatory properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.