ArticleMolecular and cellular biology2002
Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 68 citations in OpenAlex.
- Up-regulation of Arl4a gene expression by broccoli aqueous extract is associated with improved spermatogenesis in mouse testes.Biomedica : revista del Instituto Nacional de Salud · 2021Article
- Kiss1 is differentially regulated in male and female mice by the homeodomain transcription factor VAX1.Molecular and cellular endocrinology · 2021Article
- Article
- Genomics of sex allocation in the parasitoid wasp Nasonia vitripennis.BMC genomics · 2020Article
- ARF GTPases and their GEFs and GAPs: concepts and challenges.Molecular biology of the cell · 2019Review
- Coprs inactivation leads to a derepression ofFEBS open bio · 2019Article
- The evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2 are dispensable for fertility in mice.Scientific reports · 2018Article
- RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system.eLife · 2017Article
- The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice.Scientific reports · 2016Article
- ADP-ribosylation factor-like 4C (ARL4C), a novel ovarian cancer metastasis suppressor, identified by integrated genomics.American journal of translational research · 2015Article
- Article
- Perinatal exposure to low-dose methoxychlor impairs testicular development in C57BL/6 mice.PloS one · 2014Article
- Hepatic expression and cellular distribution of the glucose transporter family.World journal of gastroenterology · 2012Review
- Localization and androgen regulation of metastasis-associated protein 1 in mouse epididymis.PloS one · 2010Article
- Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signaling.Biology of reproduction · 2008Article
- Targeted disruption of Slc2a8 (GLUT8) reduces motility and mitochondrial potential of spermatozoa.Molecular membrane biology · 2008Article
- ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling.Molecular biology of the cell · 2007Article
- Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Proteomic analysis of a eukaryotic cilium.The Journal of cell biology · 2005Article
- Normal sexual development and fertility in testatin knockout mice.Molecular and cellular biology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ADP-ribosylation factor-like protein 4 (ARL4) is a 22-kDa GTP-binding protein which is abundant in testes of pubertal and adult rodents but absent in testes from prepubertal animals. During testis development, ARL4 expression starts at day 16 when the spermatogenesis proceeds to the late pachytene. In the adult testis, the ARL4 protein was detected in pre- and postmeiotic cells, spermatocytes, and spermatides, but not in spermatogonia and mature spermatozoa. Mouse Arl4-null mutants generated by targeted disruption of the Arl4 gene were viable and grew normally; male as well as female Arl4(-/-) mice were fertile. However, inactivation of the Arl4 gene resulted in a significant reduction of testis weight and sperm count by 30 and 60%, respectively, without reduction of litter size or frequency. It is suggested that the disruption of Arl4 produces a moderate retardation of germ cell development, possibly at the stage of meiosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.