ArticleMolecular and cellular biology2002
Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 101 citations in OpenAlex.
- Conformational dynamics and multimodal interaction of Paxillin with the focal adhesion targeting domain.Science advances · 2025Article
- Conformational dynamics and multi-modal interaction of Paxillin with the Focal Adhesion Targeting Domain.bioRxiv : the preprint server for biology · 2025Article
- ZINC40099027 promotes monolayer circular defect closure by a novel pathway involving cytosolic activation of focal adhesion kinase and downstream paxillin and ERK1/2.Cell and tissue research · 2022Article
- Phosphorylation of Focal Adhesion Kinase at Y925: Role in Glia-Dependent and Independent Migration through Regulating Cofilin and N-Cadherin.Molecular neurobiology · 2022Article
- Computational Design of Peptides with Improved Recognition of the Focal Adhesion Kinase FAT Domain.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications.Science signaling · 2021Review
- FAK Signaling in Rhabdomyosarcoma.International journal of molecular sciences · 2020Review
- Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin.The Journal of biological chemistry · 2017Article
- Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.Biochemistry · 2016Article
- Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin.Journal of molecular biology · 2015Article
- Conformational dynamics of the focal adhesion targeting domain control specific functions of focal adhesion kinase in cells.The Journal of biological chemistry · 2015Article
- Structural and mechanistic insights into the interaction between Pyk2 and paxillin LD motifs.Journal of molecular biology · 2014Article
- Targeting the C-terminal focal adhesion kinase scaffold in pancreatic cancer.Cancer letters · 2014Article
- FAK dimerization controls its kinase-dependent functions at focal adhesions.The EMBO journal · 2014Article
- ErbB/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions.Biochimica et biophysica acta · 2013Review
- A Novel Interaction between Pyk2 and MAP4K4 Is Integrated with Glioma Cell Migration.Journal of signal transduction · 2013Article
- Article
- PTTG induces EMT through integrin αVβ3-focal adhesion kinase signaling in lung cancer cells.Oncogene · 2012Article
- Focal adhesion kinase and endothelial cell apoptosis.Microvascular research · 2012Review
- The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation.Cellular signalling · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase whose focal adhesion targeting (FAT) domain interacts with other focal adhesion molecules in integrin-mediated signaling. Localization of activated FAK to focal adhesions is indispensable for its function. Here we describe a solution structure of the FAT domain bound to a peptide derived from paxillin, a FAK-binding partner. The FAT domain is composed of four helices that form a "right-turn" elongated bundle; the globular fold is mainly maintained by hydrophobic interactions. The bound peptide further stabilizes the structure. Certain signaling events such as phosphorylation and molecule interplay may induce opening of the helix bundle. Such conformational change is proposed to precede departure of FAK from focal adhesions, which starts focal adhesion turnover.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.