ArticleMolecular and cellular biology2002
Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 89 citations in OpenAlex.
- An integrative review of nonobvious puzzles of cellular and molecular cardiooncology.Cellular & molecular biology letters · 2023Review
- Male infertility and genitourinary birth defects: there is more than meets the eye.Fertility and sterility · 2020Review
- GRB10 and E2F3 as Diagnostic Markers of Osteoarthritis and Their Correlation with Immune Infiltration.Diagnostics (Basel, Switzerland) · 2020Article
- Resveratrol Attenuates High Glucose-Induced Vascular Endothelial Cell Injury by Activating the E2F3 Pathway.BioMed research international · 2020Article
- Diverse roles for CDK-associated activity during spermatogenesis.FEBS letters · 2019Review
- Critical Roles of E2F3 in Growth and Musculo-skeletal Phenotype in Mice.International journal of medical sciences · 2019Article
- Activation of E2F-dependent transcription by the mouse cytomegalovirus M117 protein affects the viral host range.PLoS pathogens · 2018Article
- Determination of the physiological and pathological roles of E2F3 in adult tissues.Scientific reports · 2017Article
- MicroRNA-17-92 Regulates the Transcription Factor E2F3b during Myogenesis In Vitro and In Vivo.International journal of molecular sciences · 2017Article
- E2f4 and E2f5 are essential for the development of the male reproductive system.Cell cycle (Georgetown, Tex.) · 2016Article
- E2F1-dependent miR-421 regulates mitochondrial fragmentation and myocardial infarction by targeting Pink1.Nature communications · 2015Article
- E2F1-regulated miR-30b suppresses Cyclophilin D and protects heart from ischemia/reperfusion injury and necrotic cell death.Cell death and differentiation · 2015Article
- ERBB2 deficiency alters an E2F-1-dependent adaptive stress response and leads to cardiac dysfunction.Molecular and cellular biology · 2014Article
- Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo.Cell biochemistry and function · 2014Article
- Skin Tumors Rb(eing) Uncovered.Frontiers in oncology · 2013Review
- Atypical E2F repressors and activators coordinate placental development.Developmental cell · 2012Article
- Epigenetic regulation of E2F-1-dependent Bnip3 transcription and cell death by nuclear factor-κB and histone deacetylase-1.Pediatric cardiology · 2011Article
- Review
- E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells.Nature · 2009Article
- Emerging roles of E2Fs in cancer: an exit from cell cycle control.Nature reviews. Cancer · 2009Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
The E2F1, -2, and -3 transcription factors are key downstream targets of the retinoblastoma protein (pRB) tumor suppressor that drive expression of proliferation-associated genes. Here we use mutant mouse strains to investigate E2F3's role in vivo. We show that E2F3 is essential for embryonic viability in the pure 129/Sv background but the presence of C57BL/6 alleles yields some adult survivors. Although growth retarded, surviving E2f3(-/-) animals are initially healthy. However, they die prematurely, exhibiting no obvious tumor phenotype but with the typical signs of congestive heart failure. The defects are completely distinct from those arising in E2f1 mutant mice (S. J. Field et al., Cell 85:549-561; 1996; L. Yamasaki et al., Cell 85:537-548, 1996), supporting the prevailing view that these E2Fs must have some unique biological functions in vivo. To test this model, we examined the phenotypes of E2f1 E2f3 compound mutant mice. Almost all of the developmental and age-related defects arising in the individual E2f1 or E2f3 mice were exacerbated by the mutation of the other E2f. Thus, E2F1 and E2F3 appear to play critical, overlapping roles in the development and maintenance of a variety of tissues. Importantly, this study did identify one major difference in the properties of E2F1 and E2F3: either alone or in combination with E2F1 loss, E2f3 mutation did not increase the incidence of tumor formation. These data strongly suggest that tumor suppression is a specific property of E2F1 and not E2F3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.