ArticleMolecular and cellular biology2002
BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Knockdown of DLK4 inhibits non-small cell lung cancer tumor growth by downregulating CKS2.Open life sciences · 2023Article
- Arab-Indian -530 ß-distal promoter haplotype and sickle/Hb D heterozygosis in Badagas of Nilgiris: is it suggestive of Harappan origin?Journal of genetics · 2022Article
- Homeoprotein DLX4 expression is increased in inflammatory breast cancer cases from an urban African-American population.Oncotarget · 2018Article
- Beta protein 1 homeoprotein induces cell growth and estrogen-independent tumorigenesis by binding to the estrogen receptor in breast cancer.Oncotarget · 2016Article
- The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1β and NF-κB signaling.Journal of cell science · 2015Article
- Nanostructured gold dsDNA sensor for early detection of breast cancer by beta protein 1 (BPJournal of electroanalytical chemistry (Lausanne, Switzerland) · 2015Article
- The homeoprotein DLX4 stimulates NF-κB activation and CD44-mediated tumor-mesothelial cell interactions in ovarian cancer.The American journal of pathology · 2015Article
- DLX4 is associated with orofacial clefting and abnormal jaw development.Human molecular genetics · 2015Article
- Increased copy number of the DLX4 homeobox gene in breast axillary lymph node metastasis.Cancer genetics · 2014Article
- Dual functions of the homeoprotein DLX4 in modulating responsiveness of tumor cells to topoisomerase II-targeting drugs.Cancer research · 2013Article
- DLX4 upregulates TWIST and enhances tumor migration, invasion and metastasis.International journal of biological sciences · 2012Article
- BP1, an isoform of DLX4 homeoprotein, negatively regulates BRCA1 in sporadic breast cancer.International journal of biological sciences · 2010Article
- Genome-wide analysis of BP1 transcriptional targets in breast cancer cell line Hs578T.International journal of biological sciences · 2009Article
- Amplification of the BP1 homeobox gene in breast cancer.Cancer genetics and cytogenetics · 2008Article
- Distal-less homeobox transcription factors regulate development and maturation of natural killer cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Expression level of beta protein 1 mRNA in Chinese breast cancer patients: a potential molecular marker for poor prognosis.Cancer science · 2008Article
- A homeobox gene related to Drosophila distal-less promotes ovarian tumorigenicity by inducing expression of vascular endothelial growth factor and fibroblast growth factor-2.The American journal of pathology · 2007Article
- BP1 transcriptionally activates bcl-2 and inhibits TNFalpha-induced cell death in MCF7 breast cancer cells.Breast cancer research : BCR · 2007Article
- BP1 is a negative modulator of definitive erythropoiesis.Nucleic acids research · 2006Article
- Strong linkage disequilibrium of a HbE variant with the (AT)9(T)5 repeat in the BP1 binding site upstream of the beta-globin gene in the Thai population.Journal of human genetics · 2005Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
In earlier studies we identified a putative repressor of the human beta-globin gene, termed beta protein 1 (BP1), which binds to two silencer DNA sequences upstream of the adult human beta-globin gene and to a negative control region upstream of the adult delta-globin gene. Further studies demonstrated an inverse correlation between the binding affinity of the BP1 protein for the distal beta-globin silencer sequence and the severity of sickle cell anemia, suggesting a possible role for BP1 in determining the production of hemoglobin S. We have now cloned a cDNA expressing the BP1 protein. Sequencing revealed that BP1 is a member of the homeobox gene family and belongs to the subfamily called Distal-less (DLX), genes important in early development. Further analysis showed that BP1 is an isoform of DLX4. BP1 protein has repressor function towards the beta-globin promoter, acting through the two beta-globin DNA silencers, demonstrated in transient transfection assays. Strong BP1 expression is restricted to placenta and kidney tissue, with no expression in 48 other human tissues. BP1 exhibits regulated expression in the human erythroid cell line MB-02, where its expression decreases upon induction of the beta-globin gene. BP1 is thus the first member of the DLX family with known DNA binding sites and a function in globin gene regulation.
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