ArticleMolecular and cellular biology2002
Histone H1 represses estrogen receptor alpha transcriptional activity by selectively inhibiting receptor-mediated transcription initiation.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- H1 histones: current perspectives and challenges.Nucleic acids research · 2013Review
- Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein.Molecular & cellular proteomics : MCP · 2011Article
- Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II.The Journal of cell biology · 2010Article
- CpG islands recruit a histone H3 lysine 36 demethylase.Molecular cell · 2010Article
- The DNA binding and catalytic domains of poly(ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transcription.Molecular and cellular biology · 2007Article
- Biochemical analyses of transcriptional regulatory mechanisms in a chromatin context.Methods (San Diego, Calif.) · 2007Article
- Tax abolishes histone H1 repression of p300 acetyltransferase activity at the human T-cell leukemia virus type 1 promoter.Journal of virology · 2006Article
- Effect of histone H1 on estrogen receptor status of human breast cancer MCF 7 cells.Molecular and cellular biochemistry · 2005Article
- Network of dynamic interactions between histone H1 and high-mobility-group proteins in chromatin.Molecular and cellular biology · 2004Article
- A novel Arabidopsis acetyltransferase interacts with the geminivirus movement protein NSP.The Plant cell · 2003Article
- Chromatin remodeling by nuclear receptors.Chromosoma · 2003Review
- Histone H1 enhances synergistic activation of the MMTV promoter in chromatin.The EMBO journal · 2003Article
- Chromatin exposes intrinsic differences in the transcriptional activities of estrogen receptors alpha and beta.The EMBO journal · 2003Article
- Article
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Authors and funding
3 authors.
Funding
Abstract
Chromatin is the physiological template for many nuclear processes in eukaryotes, including transcription by RNA polymerase II. In vivo, chromatin is assembled from genomic DNA, core histones, linker histones such as histone H1, and nonhistone chromatin-associated proteins. Histone H1 is thought to act as a general repressor of transcription by promoting the compaction of chromatin into higher-order structures. We have used a biochemical approach, including an in vitro chromatin assembly and transcription system, to examine the effects of histone H1 on estrogen receptor alpha (ER alpha)-mediated transcription with chromatin templates. We show that histone H1 acts as a potent repressor of ligand- and coactivator-regulated transcription by ER alpha. Histone H1 exerts its repressive effect without inhibiting the sequence-specific binding of ER alpha to chromatin or the overall extent of targeted acetylation of nucleosomal histones by the coactivator p300. Instead, histone H1 acts by blocking a specific step in the ER alpha-dependent transcription process, namely, transcription initiation, without affecting transcription reinitiation. Together, our data indicate that histone H1 acts selectively to reduce the overall level of productive transcription initiation by restricting promoter accessibility and preventing the ER alpha-dependent formation of a stable transcription pre-initiation complex.
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