ArticleJournal of the American Society for Mass Spectrometry2002
Fragmentation of phosphopeptides by atmospheric pressure MALDI and ESI/Ion trap mass spectrometry.
Article in Journal of the American Society for Mass Spectrometry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 70 citations in OpenAlex.
- Nanoparticle-based applications by atmospheric pressure matrix assisted desorption/ionization mass spectrometry.Nanoscale advances · 2023Review
- Free Radical-Initiated Peptide Sequencing Mass Spectrometry for Phosphopeptide Post-translational Modification Analysis.Journal of the American Society for Mass Spectrometry · 2019Article
- Article
- Structural characterization of monosialo-, disialo- and trisialo-gangliosides by negative ion AP-MALDI-QIT-TOF mass spectrometry with MS(n) switching.Neurochemical research · 2012Article
- Identification of proteins and phosphoproteins using pulsed Q collision induced dissociation (PQD).Journal of the American Society for Mass Spectrometry · 2011Article
- Time-resolved observation of product ions generated by 157 nm photodissociation of singly protonated phosphopeptides.Journal of the American Society for Mass Spectrometry · 2009Article
- Optimized Orbitrap HCD for quantitative analysis of phosphopeptides.Journal of the American Society for Mass Spectrometry · 2009Article
- Improved infrared multiphoton dissociation of peptides through N-terminal phosphonite derivatization.Journal of the American Society for Mass Spectrometry · 2009Article
- On-chip solid-phase extraction pre-concentration/focusing substrates coupled to atmospheric pressure matrix-assisted laser desorption/ionization ion trap mass spectrometry for high sensitivity biomolecule analysis.Rapid communications in mass spectrometry : RCM · 2009Article
- Amazing stability of phosphate-quaternary amine interactions.Journal of proteome research · 2008Article
- Methods and approaches for the comprehensive characterization and quantification of cellular proteomes using mass spectrometry.Physiological genomics · 2008Review
- Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity.Journal of proteome research · 2007Article
- The fragmentation of ethoxylated surfactants by AP-MALDI-QIT.Journal of the American Society for Mass Spectrometry · 2006Article
- Manipulating the fragmentation patterns of phosphopeptides via gas-phase boron derivatization: determining phosphorylation sites in peptides with multiple serines.Journal of the American Society for Mass Spectrometry · 2005Article
- Atmospheric pressure MALDI-FTMS of normal and chemically modified RNA.Journal of the American Society for Mass Spectrometry · 2005Article
- Fragmentation of cationized phosphotyrosine containing peptides by atmospheric pressure MALDI/Ion trap mass spectrometry.Journal of the American Society for Mass Spectrometry · 2003Article
- Angiotensin II-acetylcholine noncovalent complexes analyzed with MALDI-ion mobility-TOF MS.Journal of biomolecular techniques : JBT · 2003Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An investigation of phosphate loss from phosphopeptide ions was conducted, using both atmospheric pressure matrix-assisted laser desorption/ionization (AP MALDI) and electrospray ionization (ESI) coupled to an ion trap mass spectrometer (ITMS). These experiments were carried out on a number of phosphorylated peptides in order to investigate gas phase dephosphorylation patterns associated with phosphoserine, phosphothreonine, and phosphotyrosine residues. In particular, we explored the fragmentation patterns of phosphotyrosine containing peptides, which experience a loss of 98 Da under collision induced dissociation (CID) conditions in the ITMS. The loss of 98 Da is unexpected for phosphotyrosine, given the structure of its side chain. The fragmentation of phosphoserine and phosphothreonine containing peptides was also investigated. While phosphoserine and phosphothreonine residues undergo a loss of 98 Da under CID conditions regardless of peptide amino acid composition, phosphate loss from phosphotyrosine residues seems to be dependent on the presence of arginine or lysine residues in the peptide sequence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.