ArticleProceedings of the National Academy of Sciences of the United States of America2002
Chronic intracellular infection of alfalfa nodules by Sinorhizobium meliloti requires correct lipopolysaccharide core.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 137 citations in OpenAlex.
- Exploring the role of symbiotic modifier peptidases in the legume - rhizobium symbiosis.Archives of microbiology · 2024Review
- Article
- Competition, Nodule Occupancy, and Persistence of Inoculant Strains: Key Factors in theFrontiers in plant science · 2021Review
- Structure of the unusualThe Journal of biological chemistry · 2020Article
- A Bifunctional UDP-Sugar 4-Epimerase Supports Biosynthesis of Multiple Cell Surface Polysaccharides in Sinorhizobium meliloti.Journal of bacteriology · 2019Article
- Complete Genome Sequence of Sinorhizobium Phage ΦM6, the First Terrestrial Phage of a Marine Phage Group.Microbiology resource announcements · 2018Article
- Novel Genes and Regulators That Influence Production of Cell Surface Exopolysaccharides in Sinorhizobium meliloti.Journal of bacteriology · 2018Article
- Article
- Morphotype of bacteroids in different legumes correlates with the number and type of symbiotic NCR peptides.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Bacterial Molecular Signals in the Sinorhizobium fredii-Soybean Symbiosis.International journal of molecular sciences · 2016Article
- Sinorhizobium meliloti Phage ΦM9 Defines a New Group of T4 Superfamily Phages with Unusual Genomic Features but a Common T=16 Capsid.Journal of virology · 2015Article
- Effects of the Bradyrhizobium japonicum waaL (rfaL) Gene on Hydrophobicity, Motility, Stress Tolerance, and Symbiotic Relationship with Soybeans.International journal of molecular sciences · 2015Article
- Lipopolysaccharide O-chain core region required for cellular cohesion and compaction of in vitro and root biofilms developed by Rhizobium leguminosarum.Applied and environmental microbiology · 2015Article
- Transcriptional regulator LsrB of Sinorhizobium meliloti positively regulates the expression of genes involved in lipopolysaccharide biosynthesis.Applied and environmental microbiology · 2014Article
- Lipopolysaccharides in diazotrophic bacteria.Frontiers in cellular and infection microbiology · 2014Review
- The Sinorhizobium meliloti essential porin RopA1 is a target for numerous bacteriophages.Journal of bacteriology · 2013Article
- The role of bacterial biofilms and surface components in plant-bacterial associations.International journal of molecular sciences · 2013Review
- Article
- Sinorhizobium meliloti ExoR is the target of periplasmic proteolysis.Journal of bacteriology · 2012Article
- A positive correlation between bacterial autoaggregation and biofilm formation in native Sinorhizobium meliloti isolates from Argentina.Applied and environmental microbiology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Our analyses of lipopolysaccharide mutants of Sinorhizobium meliloti offer insights into how this bacterium establishes the chronic intracellular infection of plant cells that is necessary for its nitrogen-fixing symbiosis with alfalfa. Derivatives of S. meliloti strain Rm1021 carrying an lpsB mutation are capable of colonizing curled root hairs and forming infection threads in alfalfa in a manner similar to a wild-type strain. However, developmental abnormalities occur in the bacterium and the plant at the stage when the bacteria invade the plant nodule cells. Loss-of-function lpsB mutations, which eliminate a protein of the glycosyltransferase I family, cause striking changes in the carbohydrate core of the lipopolysaccharide, including the absence of uronic acids and a 40-fold relative increase in xylose. We also found that lpsB mutants were sensitive to the cationic peptides melittin, polymyxin B, and poly-l-lysine, in a manner that paralleled that of Brucella abortus lipopolysaccharide mutants. Sensitivity to components of the plant's innate immune system may be part of the reason that this mutant is unable to properly sustain a chronic infection within the cells of its host-plant alfalfa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.