ArticleProceedings of the National Academy of Sciences of the United States of America2002
Enhancer action in trans is permitted throughout the Drosophila genome.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Article
- Genome-Wide Association Study and transcriptome analysis reveals a complex gene network that regulates opsin gene expression and cell fate determination inbioRxiv : the preprint server for biology · 2024Article
- Development of a New Model System to Study Long-Distance Interactions Supported by Architectural Proteins.International journal of molecular sciences · 2024Article
- Transvection between nonallelic genomic positions in Drosophila.G3 (Bethesda, Md.) · 2024Article
- Multi-Scale Organization of theGenes · 2021Review
- Position Effects Influence Transvection inGenetics · 2019Article
- Highly structured homolog pairing reflects functional organization of the Drosophila genome.Nature communications · 2019Article
- The Role of Insulators in Transgene Transvection inGenetics · 2019Article
- Two modes of transvection at the eyes absent gene of Drosophila demonstrate plasticity in transcriptional regulatory interactions in cis and in trans.PLoS genetics · 2019Article
- Selective interactions between diverse STEs organize the ANT-C Hox cluster.Scientific reports · 2018Article
- Article
- Transvection.Current biology : CB · 2017Article
- Article
- The IgH locus 3' cis-regulatory super-enhancer co-opts AID for allelic transvection.Oncotarget · 2017Article
- Interallelic Transcriptional Enhancement as an in Vivo Measure of Transvection in Drosophila melanogaster.G3 (Bethesda, Md.) · 2016Article
- Article
- Determinants of Chromosome Architecture: Insulator Pairing in cis and in trans.PLoS genetics · 2016Article
- An Organizational Hub of Developmentally Regulated Chromatin Loops in the Drosophila Antennapedia Complex.Molecular and cellular biology · 2015Article
- Temperature stress mediates decanalization and dominance of gene expression in Drosophila melanogaster.PLoS genetics · 2015Article
- Transvection-based gene regulation in Drosophila is a complex and plastic trait.G3 (Bethesda, Md.) · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Interactions between paired homologous genes can lead to changes in gene expression. Such trans-regulatory effects exemplify transvection and are displayed by many genes in Drosophila, in which homologous chromosomes are paired somatically. Transvection involving the yellow cuticle pigmentation gene can occur by at least two mechanisms, one involving the trans-action of enhancers on a paired promoter and a second involving pairing-mediated bypass of a chromatin insulator. A system was developed to evaluate whether the action of the yellow enhancers in trans could be reconstituted outside of the natural near telomeric location of the yellow gene. To this end, transgenic flies were generated that carried a yellow gene modified by the inclusion of strategically placed recognition sites for the Cre and FLP recombinases. Independent action of the recombinases produced a pair of derivative alleles, one enhancerless and the other promoterless, at each transgene location. Transvection between the derivatives was assessed by the degree of interallelic complementation. Complementation was observed at all eight sites tested. These studies demonstrate that yellow transvection can occur at multiple genomic locations and indicate that the Drosophila genome generally is permissive to enhancer action in trans.
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