ArticleProceedings of the National Academy of Sciences of the United States of America2002
Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 94 citations in OpenAlex.
- Trial
- Telomeres: an organized string linking plants and mammals.Biology direct · 2024Review
- High-throughput single telomere analysis using DNA microarray and fluorescent in situ hybridization.Nucleic acids research · 2024Article
- Genomic instability in the naturally and prematurely aged myocardium.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Selective Elimination of Osteosarcoma Cell Lines with Short Telomeres by Ataxia Telangiectasia and Rad3-Related Inhibitors.ACS pharmacology & translational science · 2020Article
- Dichotomy between the transcriptomic landscape of naturally versus accelerated aged murine hearts.Scientific reports · 2020Article
- Fluorescence spectroscopic detection and measurement of single telomere molecules.Nucleic acids research · 2018Article
- From "Cellular" RNA to "Smart" RNA: Multiple Roles of RNA in Genome Stability and Beyond.Chemical reviews · 2018Review
- Associations Between Cellular Aging Markers and Metabolic Syndrome: Findings From the CARDIA Study.The Journal of clinical endocrinology and metabolism · 2018Article
- Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells.Open biology · 2017Review
- 5p deletions: Current knowledge and future directions.American journal of medical genetics. Part C, Seminars in medical genetics · 2015Review
- Article
- Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance.BioMed research international · 2014Review
- In situ visualization of telomere elongation patterns in human cells.Nucleic acids research · 2013Article
- A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization.Molecular biology of the cell · 2013Article
- Novel telomerase-increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis.EMBO molecular medicine · 2012Article
- Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells.Cell research · 2012Article
- Telomerase regulation.Mutation research · 2012Review
- Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.Molecular and cellular biology · 2011Article
- Two RNA subunits and POT1a are components of Arabidopsis telomerase.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Prolonged growth of murine embryonic stem (ES) cells lacking the telomerase reverse transcriptase, mTert, results in a loss of telomere DNA and an increased incidence of end-to-end fusions and aneuploidy. Furthermore, loss of only one copy of mTert also results in telomere shortening intermediate between wild-type (wt) and mTert-null ES cells [Liu, Y., Snow, B. E., Hande, M. P., Yeung, D., Erdmann, N. J., Wakeham, A., Itie, A., Siderovski, D. P., Lansdorp, P. M., Robinson, M. O. & Harrington, L. (2000) Curr. Biol. 10, 1459-1462]. Unexpectedly, although average telomere length in mTert(+/-) ES cells declined to a similar level as mTert-null ES cells, mTert(+/-) ES cell lines retained a minimal telomeric DNA signal at all chromosome ends. Consequently, no end-to-end fusions and genome instability were observed in the latest passages of mTert(+/-) ES cell lines. These data uncover a functional distinction between the dosage-dependent function of telomerase in average telomere-length maintenance and the selective maintenance of critically short telomeres in cells heterozygous for mTert. In normal and tumor cells, we suggest that telomerase activity insufficient to maintain a given average telomere length may, nonetheless, provide a protective advantage from end-to-end fusion and genome instability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.