ArticleProceedings of the National Academy of Sciences of the United States of America2002
Origin of sphinx, a young chimeric RNA gene in Drosophila melanogaster.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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71 citing papers in PubMed.
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- From Genomic Fossils to Functional Elements: The Evolving Story of Pseudogenes.Advanced genetics (Hoboken, N.J.) · 2025Review
- Protein evidence of unannotated ORFs ineLife · 2022Article
- Nuku, a family of primate retrocopies derived from KU70.G3 (Bethesda, Md.) · 2021Article
- RetroScan: An Easy-to-Use Pipeline for Retrocopy Annotation and Visualization.Frontiers in genetics · 2021Article
- Review
- Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates.eLife · 2020Article
- Evolutionary patterns of chimeric retrogenes in Oryza species.Scientific reports · 2019Article
- Aggression and courtship differences found in Drosophila melanogaster from two different microclimates at Evolution Canyon, Israel.Scientific reports · 2019Article
- The Genomic Impact of Gene Retrocopies: What Have We Learned from Comparative Genomics, Population Genomics, and Transcriptomic Analyses?Genome biology and evolution · 2017Article
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- The genome of the crustaceaneLife · 2016Article
- Altered Transcription and Neofunctionalization of Duplicated Genes Rescue the Harmful Effects of a Chimeric Gene inThe Plant cell · 2016Article
- Correlated expression of retrocopies and parental genes in zebrafish.Molecular genetics and genomics : MGG · 2016Article
- The life history of retrocopies illuminates the evolution of new mammalian genes.Genome research · 2016Article
- Origin and evolution of GATA2a and GATA2b in teleosts: insights from tongue sole, Cynoglossus semilaevis.PeerJ · 2016Article
- Evolutionary fate and implications of retrocopies in the African coelacanth genome.BMC genomics · 2015Article
- Adaptive regulation of testis gene expression and control of male fertility by the Drosophila hairpin RNA pathway. [Corrected].Molecular cell · 2015Article
- Novel LMW glutenin subunit genes from wild emmer wheat (Triticum turgidum ssp. dicoccoides) in relation to Glu-3 evolution.Development genes and evolution · 2015Article
- New genes contribute to genetic and phenotypic novelties in human evolution.Current opinion in genetics & development · 2014Review
11 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
Non-protein-coding RNA genes play an important role in various biological processes. How new RNA genes originated and whether this process is controlled by similar evolutionary mechanisms for the origin of protein-coding genes remains unclear. A young chimeric RNA gene that we term sphinx (spx) provides the first insight into the early stage of evolution of RNA genes. spx originated as an insertion of a retroposed sequence of the ATP synthase chain F gene at the cytological region 60DB since the divergence of Drosophila melanogaster from its sibling species 2-3 million years ago. This retrosequence, which is located at 102F on the fourth chromosome, recruited a nearby exon and intron, thereby evolving a chimeric gene structure. This molecular process suggests that the mechanism of exon shuffling, which can generate protein-coding genes, also plays a role in the origin of RNA genes. The subsequent evolutionary process of spx has been associated with a high nucleotide substitution rate, possibly driven by a continuous positive Darwinian selection for a novel function, as is shown in its sex- and development-specific alternative splicing. To test whether spx has adapted to different environments, we investigated its population genetic structure in the unique "Evolution Canyon" in Israel, revealing a similar haplotype structure in spx, and thus similar evolutionary forces operating on spx between environments.
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