ArticleProceedings of the National Academy of Sciences of the United States of America2002
Inhibition of Xenopus oocyte meiotic maturation by catalytically inactive protein kinase A.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 61 citations in OpenAlex.
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- Dynamic expression of Epac and Rap1 in mouse oocytes and preimplantation embryos.Experimental and therapeutic medicine · 2018Article
- The cyclic AMP signaling pathway: Exploring targets for successful drug discovery (Review).Molecular medicine reports · 2016Review
- In vitro induction of oocyte maturation and steroidogenesis by gonadotropins, insulin, calcitonin and growth factor in an estuarine flat head grey mullet, Mugil cephalus L.Fish physiology and biochemistry · 2014Article
- MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The DNA damage response in mammalian oocytes.Frontiers in genetics · 2013Article
- Pioneering the Xenopus oocyte and egg extract system.The Journal of biological chemistry · 2012Article
- Effect of H89 on the meiotic resumption of pig oocytes.Reproductive medicine and biology · 2011Article
- Rab32 regulates melanosome transport in Xenopus melanophores by protein kinase a recruitment.Current biology : CB · 2007Article
- Cdc25 and Wee1: analogous opposites?Cell division · 2007Article
- Cyclooxygenase-2 inhibits UVB-induced apoptosis in mouse skin by activating the prostaglandin E2 receptors, EP2 and EP4.Cancer research · 2007Article
- Changes in regulatory phosphorylation of Cdc25C Ser287 and Wee1 Ser549 during normal cell cycle progression and checkpoint arrests.Molecular biology of the cell · 2005Article
- Differential phosphorylation controls Maskin association with eukaryotic translation initiation factor 4E and localization on the mitotic apparatus.Molecular and cellular biology · 2005Article
- Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility.The Journal of clinical investigation · 2004Article
- Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3.Genes & development · 2004Article
- Xp38gamma/SAPK3 promotes meiotic G(2)/M transition in Xenopus oocytes and activates Cdc25C.The EMBO journal · 2003Article
- beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progesterone induces G2-arrested Xenopus oocytes to develop into fertilizable eggs in a process called meiotic maturation. Protein kinase A (PKA), the cAMP-dependent protein kinase, has long been known to be a potent inhibitor of meiotic maturation, but little information is available on how PKA functions. We have cloned two Xenopus PKA catalytic subunit isoforms, XPKAalpha and XPKAbeta. These proteins are 89% identical and both inhibit progesterone-induced meiotic maturation when overexpressed at low levels, suggesting that PKA activity is tightly regulated in the oocyte. Unexpectedly, catalytically inactive XPKA mutants are able to block progesterone-induced maturation as efficiently as the wild-type active XPKA. These mutants also block meiotic maturation induced by Mos, but are less efficient at inhibiting Cdc25C-induced maturation. Our results indicate that PKA can inhibit meiotic maturation by a novel mechanism, which does not require its kinase activity and is also independent of binding to the PKA regulatory subunits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.