ArticleThe Biochemical journal2002
Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells.
Article in The Biochemical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Unveiling the role of GAS41 in cancer progression.Cancer cell international · 2023Review
- Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin.Molecular cell · 2023Article
- Mechanistic insights into genomic structure and functions of a novel oncogene YEATS4.Frontiers in cell and developmental biology · 2023Review
- Muscleblind-like 1 suppresses breast cancer metastatic colonization and stabilizes metastasis suppressor transcripts.Genes & development · 2016Article
- Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome.International journal of epidemiology · 2015Article
- Xenopus TACC1 is a microtubule plus-end tracking protein that can regulate microtubule dynamics during embryonic development.Cytoskeleton (Hoboken, N.J.) · 2015Article
- TACC3 deregulates the DNA damage response and confers sensitivity to radiation and PARP inhibition.Oncogene · 2015Article
- Mouse dead end 1-β interacts with c-Jun and stimulates activator protein 1 transactivation.Molecular medicine reports · 2015Article
- Knockdown of YEATS4 inhibits colorectal cancer cell proliferation and induces apoptosis.American journal of translational research · 2015Article
- Prognosis significance of HER2 status and TACC1 expression in patients with gastric carcinoma.Medical oncology (Northwood, London, England) · 2014Article
- The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.The Journal of biological chemistry · 2014Article
- YEATS4 is a novel oncogene amplified in non-small cell lung cancer that regulates the p53 pathway.Cancer research · 2013Article
- GAS41 amplification results in overexpression of a new spindle pole protein.Genes, chromosomes & cancer · 2012Article
- The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.BMC molecular biology · 2010Article
- The microtubule-associated protein tumor overexpressed gene/cytoskeleton-associated protein 5 is necessary for myelin basic protein expression in oligodendrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Interaction of TACC proteins with the FHL family: implications for ERK signaling.Journal of cell communication and signaling · 2007Article
- GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation.Molecular and cellular biology · 2006Article
- Cellular effect of high doses of silica-coated quantum dot profiled with high throughput gene expression analysis and high content cellomics measurements.Nano letters · 2006Article
- GAS41 interacts with transcription factor AP-2beta and stimulates AP-2beta-mediated transactivation.Nucleic acids research · 2006Article
- The Xenopus TACC homologue, maskin, functions in mitotic spindle assembly.Molecular biology of the cell · 2005Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Dysregulation of the human transforming acidic coiled-coil (TACC) proteins is thought to be important in the evolution of breast cancer and multiple myeloma. However, the exact role of these proteins in the oncogenic process is currently unknown. Using the full-length TACC1 protein as bait to screen a human mammary epithelial cDNA library, we have identified two genes that are also amplified and overexpressed in tumours derived from different cellular origins. TACC1 interacts with the C-terminus of both the microtubule-associated colonic and hepatic tumour overexpressed (ch-TOG) protein, and the oncogenic transcription factor glioma amplified sequence 41/NuMA binding protein 1 (GAS41/NuBI1; where NuMA stands for nuclear mitotic apparatus protein 1). This suggests that the TACC proteins can form multiple complexes, dysregulation of which may be an important step during tumorigenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.