ArticleThe Biochemical journal2002
Cyclophilin-A is involved in excitotoxin-induced caspase activation in rat neuronal B50 cells.
Article in The Biochemical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- Comparative Proteomic Analysis of Advanced Ovarian Cancer Tissue to Identify Potential Biomarkers of Responders and Nonresponders to First-Line Chemotherapy of Carboplatin and Paclitaxel.Biomarkers in cancer · 2016Article
- Potential of immunosuppressive agents in cerebral ischaemia.The Indian journal of medical research · 2011Review
- Implications of ER stress, the unfolded protein response, and pro- and anti-apoptotic protein fingerprints in human monocyte-derived dendritic cells treated with alcohol.Alcoholism, clinical and experimental research · 2010Article
- Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation.The Biochemical journal · 2009Article
- Estrogen induces caspase-dependent cell death during hypothalamic development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Dynamin-2-dependent targeting of mannheimia haemolytica leukotoxin to mitochondrial cyclophilin D in bovine lymphoblastoid cells.Infection and immunity · 2008Article
- Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia.The Journal of experimental medicine · 2007Article
- Discovering novel chemical inhibitors of human cyclophilin A: virtual screening, synthesis, and bioassay.Bioorganic & medicinal chemistry · 2006Article
- Roles of cyclophilins in cancers and other organ systems.World journal of surgery · 2005Review
- Crystallization and preliminary X-ray crystallographic studies of human cyclophilin J.Acta crystallographica. Section F, Structural biology and crystallization communications · 2005Article
- The cyclophilins.Genome biology · 2005Review
- Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis.The Biochemical journal · 2004Article
- Effects of altered expression and localization of cyclophilin A on differentiation of p19 embryonic carcinoma cells.Cellular and molecular neurobiology · 2003Article
- Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria.Molecular neurobiology · 2003Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamate and the NO donor, nitroprusside, synergistically induced the death of B50 cells from a rat CNS-derived neuroblastoma cell line. With low [nitroprusside] (10 microM) both nitroprusside and glutamate were required. Under these conditions, nuclei became pyknotic and caspases were activated. The activities of caspase-3 and caspase-6 (effector caspases) were higher than those of caspase-8 and caspase-9 (initiator caspases). The activation of all four caspases was inhibited by cyclosporin A, with the order of susceptibility caspase-8=caspase-9=caspase-6>caspase-3. To identify the possible locus of cyclosporin A action, we used an antisense oligodeoxynucleotide to suppress the level of cyclophilin-A to<5% of its control value. Cyclophilin-A suppression largely reproduced the inhibitory effects of cyclosporin A. These results provide the first indication that cyclophilin-A participates in the activation of the caspase cascade in neuronal cells, in particular in the form of cascade elicited by excitotoxic stimuli. It is concluded that neuroprotection by cyclosporin A against excitotoxin-induced apoptosis is, at least partly, due to inhibition of cyclophilin-A.
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