ArticleThe Journal of experimental medicine2002
Major histocompatibility complex class II presentation of cell-associated antigen is mediated by CD8alpha+ dendritic cells in vivo.
Article in The Journal of experimental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
- In vivo dendritic cell reprogramming for cancer immunotherapy.Science (New York, N.Y.) · 2024Article
- Intestinal cDC1s provide cues required for CD4+ T cell-mediated resistance to Cryptosporidium.The Journal of experimental medicine · 2024Article
- Article
- Intestinal cDC1s provide IL-12 dependent and independent functions required for CD4bioRxiv : the preprint server for biology · 2023Article
- Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy.Journal of hematology & oncology · 2022Review
- Dendritic cells in cancer immunology.Cellular & molecular immunology · 2022Review
- cDC1 prime and are licensed by CD4Nature · 2020Article
- Transfer of antigen from human B cells to dendritic cells.Molecular immunology · 2014Article
- Peripheral CD4(+) T-cell tolerance is induced in vivo by rare antigen-bearing B cells in follicular, marginal zone, and B-1 subsets.European journal of immunology · 2013Article
- Antigen cross-presentation: extending recent laboratory findings to therapeutic intervention.Clinical and experimental immunology · 2011Review
- Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells.The Journal of clinical investigation · 2009Article
- Article
- Editing antigen presentation: antigen transfer between human B lymphocytes and macrophages mediated by class A scavenger receptors.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection.Cellular microbiology · 2008Article
- Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin.The Journal of clinical investigation · 2008Article
- Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
- Lymphocytes genetically modified to express tumor antigens target DCs in vivo and induce antitumor immunity.The Journal of clinical investigation · 2007Article
- Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo.Nature reviews. Immunology · 2007Review
- The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antigen-specific B cells express major histocompatibility complex class II and can present antigen directly to T cells. Adoptive transfer experiments using transgenic B and T cells demonstrated that antigen-specific B cells can also efficiently transfer antigen to another cell for presentation to T cells in vivo. To identify the antigen-presenting cell that receives antigens from B cells, a strategy was developed to follow the traffic of B cell-derived proteins in vivo. B cells were labeled with the fluorescent dye CFSE and loaded with antigen, before adoptive transfer into recipient mice. Populations of splenocytes from the recipient mice were later assayed for the presence of fluorescent proteins and for the ability to activate T cells. A small number of CD8alpha+CD4-CD11b(lo) dendritic cells (DCs) contain proteins transferred from B cells and these DCs effectively present antigens derived from the B cells to T cells. The results suggest that CD8alpha+ DCs sample the cells and membranes in their environment for presentation to T cells circulating through the T cell zone. This function of CD8alpha+ DCs may be relevant to the priming of an immune response or the induction of T cell tolerance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.