ArticleThe Journal of cell biology2002
Induction of secretory pathway components in yeast is associated with increased stability of their mRNA.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Expression of RRBP1 in epithelial ovarian cancer and its clinical significance.Bioscience reports · 2019Trial
- ER biogenesis without stress: how the ribosome receptor, p180, defines a developmental program beyond the UPR.Frontiers in cell and developmental biology · 2025Article
- CircVPS13C promotes pituitary adenoma growth by decreasing the stability of IFITM1 mRNA via interacting with RRBP1.Oncogene · 2022Article
- Determinants of the temperature adaptation of mRNA degradation.Nucleic acids research · 2022Article
- Alternative 3' UTRs play a widespread role in translation-independent mRNA association with the endoplasmic reticulum.Cell reports · 2021Article
- RRBP1 is highly expressed in bladder cancer and is associated with migration and invasion.Oncology letters · 2020Article
- An RNA-centric dissection of host complexes controlling flavivirus infection.Nature microbiology · 2019Article
- Metabolic reprogramming during purine stress in the protozoan pathogen Leishmania donovani.PLoS pathogens · 2014Article
- Speed controls in translating secretory proteins in eukaryotes--an evolutionary perspective.PLoS computational biology · 2014Article
- Article
- Primary role for endoplasmic reticulum-bound ribosomes in cellular translation identified by ribosome profiling.The Journal of biological chemistry · 2012Article
- Review
- Cell-to-Cell Communication Circuits: Quantitative Analysis of Synthetic Logic Gates.Frontiers in physiology · 2012Article
- p180 promotes the ribosome-independent localization of a subset of mRNA to the endoplasmic reticulum.PLoS biology · 2012Article
- Quantitative analysis of the transcription control mechanism.Molecular systems biology · 2010Article
- Enhancement of procollagen biosynthesis by p180 through augmented ribosome association on the endoplasmic reticulum in response to stimulated secretion.The Journal of biological chemistry · 2010Article
- Knockdown of p180 eliminates the terminal differentiation of a secretory cell line.Molecular biology of the cell · 2009Article
- A block in endoplasmic reticulum-to-Golgi trafficking inhibits phospholipid synthesis and induces neutral lipid accumulation.The Journal of biological chemistry · 2008Article
- HacA-independent induction of chaperone-encoding gene bipA in Aspergillus niger strains overproducing membrane proteins.Applied and environmental microbiology · 2006Article
- Detection and analysis of spliced chimeric mRNAs in sequence databanks.Nucleic acids research · 2003Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The overexpression of certain membrane proteins is accompanied by a striking proliferation of intracellular membranes. One of the best characterized inducers of membrane proliferation is the 180-kD mammalian ribosome receptor (p180), whose expression in yeast results in increases in levels of mRNAs encoding proteins that function in the secretory pathway, and an elevation in the cell's ability to secrete proteins. In this study we demonstrate that neither the unfolded protein response nor increased transcription accounts for membrane proliferation or the observed increase in secretory pathway mRNAs. Rather, p180-induced up-regulation of certain secretory pathway transcripts is due to a p180-mediated increase in the longevity of these mRNA species, as determined by measurements of transcriptional activity and specific mRNA turnover. Moreover, we show that the longevity of mRNA in general is substantially promoted through the process of its targeting to the membrane of the endoplasmic reticulum. With respect to the terminal differentiation of secretory tissues, results from this model system provide insights into how the expression of a single protein, p180, could result in substantial morphological and functional changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.