ArticleThe Journal of cell biology2002
Listeriolysin O: a genuine cytolysin optimized for an intracellular parasite.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- The spectrum of lysosomal stress and damage responses: from mechanosensing to inflammation.EMBO reports · 2025Review
- Bactofection, Bacterial-Mediated Vaccination, and Cancer Therapy: Current Applications and Future Perspectives.Vaccines · 2024Review
- Aptamers: precision tools for diagnosing and treating infectious diseases.Frontiers in cellular and infection microbiology · 2024Review
- Meta-Analysis of the Prevalence of Porcine Zoonotic Bacterial Pathogens in India: A 13-Year (2010-2023) Study.Pathogens (Basel, Switzerland) · 2023Review
- Review
- The Complex Role of Lactic Acid Bacteria in Food Detoxification.Nutrients · 2022Review
- Therapeutic Vaccines for Tuberculosis: An Overview.Frontiers in immunology · 2022Review
- Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection.Scientific reports · 2021Article
- Biopolymer-based Carriers for DNA Vaccine Design.Angewandte Chemie (International ed. in English) · 2021Review
- Breaching the Bacterial Envelope: The Pivotal Role of Perforin-2 (MPEG1) Within Phagocytes.Frontiers in immunology · 2021Review
- pH-triggered endosomal escape of pore-forming Listeriolysin O toxin-coated gold nanoparticles.Journal of nanobiotechnology · 2019Article
- A potential bio-control agent from baical skullcap root against listeriosis via the inhibition of sortase A and listeriolysin O.Journal of cellular and molecular medicine · 2019Article
- Reactive oxygen species inhibitsFood science & nutrition · 2018Article
- A Window toPathogens (Basel, Switzerland) · 2018Review
- RNA Helicase Important for Listeria monocytogenes Hemolytic Activity and Virulence Factor Expression.Infection and immunity · 2016Article
- Novel inhibitor discovery and the conformational analysis of inhibitors of listeriolysin O via protein-ligand modeling.Scientific reports · 2015Article
- The RAB5-GEF function of RIN1 regulates multiple steps during Listeria monocytogenes infection.Traffic (Copenhagen, Denmark) · 2014Article
- Group B streptococcal haemolysin and pigment, a tale of twins.FEMS microbiology reviews · 2014Review
- Cytoplasmic replication of Staphylococcus aureus upon phagosomal escape triggered by phenol-soluble modulin α.Cellular microbiology · 2014Article
- Who's really in control: microbial regulation of protein trafficking in the epithelium.American journal of physiology. Cell physiology · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cholesterol-dependent cytolysins (CDCs)* are produced by a large number of pathogenic gram-positive bacteria. A member of this family, listeriolysin O (LLO), is produced by the intracellular pathogen Listeria monocytogenes. A unique feature of LLO is its low optimal pH activity (approximately 6) which permits escape of the bacterium from the phagosome into the host cell cytosol without damaging the plasma membrane of the infected cell. In a recent study (Glomski et al., 2002, this issue), Portnoy's group has addressed the molecular mechanism underlying the pH sensitivity of LLO. Unexpectedly, a single amino acid substitution in LLO L461T results in a molecule more active at neutral pH and promoting premature permeabilization of the infected cells, leading to attenuated virulence. This finding highlights how subtle changes in proteins can be exploited by bacterial pathogens to establish and maintain the integrity of their specific niches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.