ArticleGenetics2002
Linkage disequilibrium in domestic sheep.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed.
- Genomic architecture of purebred and crossbred Moghani lambs with Texel and Booroola sheep.Scientific reports · 2025Article
- Genome-wide study of linkage disequilibrium, population structure, and inbreeding in Iranian indigenous sheep breeds.PloS one · 2023Article
- Development and Validation of an Open Access SNP Array for Nile Tilapia (G3 (Bethesda, Md.) · 2020Article
- Discovery and characterization of functional modules associated with body weight in broilers.Scientific reports · 2019Article
- Linkage disequilibrium in Brazilian Santa Inês breed, Ovis aries.Scientific reports · 2018Article
- Article
- Genomic characterization of the Braque Français type Pyrénées dog and relationship with other breeds.PloS one · 2018Article
- Association mapping analysis of fiber yield and quality traits in Upland cotton (Gossypium hirsutum L.).Molecular genetics and genomics : MGG · 2017Article
- Genomic regions and pathways associated with gastrointestinal parasites resistance in Santa Inês breed adapted to tropical climate.Journal of animal science and biotechnology · 2017Article
- Genetic diversity, linkage disequilibrium, and association mapping analyses of Gossypium barbadense L. germplasm.PloS one · 2017Article
- Assessing accuracy of imputation using different SNP panel densities in a multi-breed sheep population.Genetics, selection, evolution : GSE · 2016Article
- Linkage disequilibrium, persistence of phase and effective population size estimates in Hereford and Braford cattle.BMC genetics · 2016Article
- Genome-wide linkage disequilibrium and genetic diversity in five populations of Australian domestic sheep.Genetics, selection, evolution : GSE · 2015Article
- Temporal dynamics of linkage disequilibrium in two populations of bighorn sheep.Ecology and evolution · 2015Article
- Extent of Linkage Disequilibrium and Effective Population Size in Four South African Sanga Cattle Breeds.Frontiers in genetics · 2015Article
- Identification of associated SSR markers for yield component and fiber quality traits based on frame map and Upland cotton collections.PloS one · 2015Article
- Genomic prediction of genetic merit using LD-based haplotypes in the Nordic Holstein population.BMC genomics · 2014Article
- QTLs associated with dry matter intake, metabolic mid-test weight, growth and feed efficiency have little overlap across 4 beef cattle studies.BMC genomics · 2014Article
- The application of genome-wide SNP genotyping methods in studies on livestock genomes.Journal of applied genetics · 2014Review
- Genome-wide two-marker linkage disequilibrium mapping of quantitative trait loci.BMC genetics · 2014Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The last decade has seen a dramatic increase in the number of livestock QTL mapping studies. The next challenge awaiting livestock geneticists is to determine the actual genes responsible for variation of economically important traits. With the advent of high density single nucleotide polymorphism (SNP) maps, it may be possible to fine map genes by exploiting linkage disequilibrium between genes of interest and adjacent markers. However, the extent of linkage disequilibrium (LD) is generally unknown for livestock populations. In this article microsatellite genotype data are used to assess the extent of LD in two populations of domestic sheep. High levels of LD were found to extend for tens of centimorgans and declined as a function of marker distance. However, LD was also frequently observed between unlinked markers. The prospects for LD mapping in livestock appear encouraging provided that type I error can be minimized. Properties of the multiallelic LD coefficient D' were also explored. D' was found to be significantly related to marker heterozygosity, although the relationship did not appear to unduly influence the overall conclusions. Of potentially greater concern was the observation that D' may be skewed when rare alleles are present. It is recommended that the statistical significance of LD is used in conjunction with coefficients such as D' to determine the true extent of LD.
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