ArticleGenetics2002
Multiple effects of genetic background on variegated transgene expression in mice.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- New considerations for hiPSC-based models of neuropsychiatric disorders.Molecular psychiatry · 2019Review
- Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice.Investigative ophthalmology & visual science · 2018Article
- Use of C57BL/6N mice on the variety of immunological researches.Laboratory animal research · 2017Review
- Comparison of humoral and cell-mediated immunity in three different C57BL/6N mouse substrains.Laboratory animal research · 2017Article
- Comparative study of the immunological characteristics of three different C57BL/6N mouse substrains.Laboratory animal research · 2017Article
- Transgene expression in the Nop-tTA driver line is not inherently restricted to the entorhinal cortex.Brain structure & function · 2016Article
- Effect of crossing C57BL/6 and FVB mouse strains on basal cytokine expression.Mediators of inflammation · 2015Article
- A previously functional tetracycline-regulated transactivator fails to target gene expression to the bone.BMC research notes · 2011Article
- Selection against Robertsonian fusions involving housekeeping genes in the house mouse: integrating data from gene expression arrays and chromosome evolution.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2010Article
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- Engineering disease resistant cattle.Transgenic research · 2005Review
- High-level expression of single-chain Fv-Fc fusion protein in serum and egg white of genetically manipulated chickens by using a retroviral vector.Journal of virology · 2005Article
- Early and late HHV-6 gene transcripts in multiple sclerosis lesions and normal appearing white matter.Brain : a journal of neurology · 2005Article
- Functional characterization of the human atrial essential myosin light chain (hALC-1) in a transgenic rat model.Journal of molecular medicine (Berlin, Germany) · 2004Article
- Transgene methylation in mice reflects copy number but not expression level.Molecular biotechnology · 2004Article
- On the use of post-transcriptional processing elements in transgenes.Transgenic research · 2004Article
- Germline modification of domestic animals.Animal reproductionArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BLG/7 transgenic mice express an ovine beta-lactoglobulin transgene during lactation. Unusually, transgene expression levels in milk differ between siblings. This variable expression is due to variegated transgene expression in the mammary gland and is reminiscent of position-effect variegation. The BLG/7 line was created and maintained on a mixed CBA x C57BL/6 background. We have investigated the effect on transgene expression of backcrossing for 13 generations into these backgrounds. Variable transgene expression was observed in all populations examined, confirming that it is an inherent property of the transgene array at its site of integration. There were also strain-specific effects on transgene expression that appear to be independent of the inherent variegation. The transgene, compared to endogenous milk protein genes, is specifically susceptible to inbreeding depression. Outcrossing restored transgene expression levels to that of the parental population; thus suppression was not inherited. Finally, no generation-dependent decrease in mean expression levels was observed in the parental population. Thus, although the BLG/7 transgene is expressed in a variegated manner, there was no generation-associated accumulated silencing of transgene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.