ArticleGenetics2002
Identification and characterization of the genes encoding the core histones and histone variants of Neurospora crassa.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- A translocation within the Ogataea species complex alters local subtelomeric chromatin while maintaining overall genome organization.G3 (Bethesda, Md.) · 2026Article
- A Translocation within thebioRxiv : the preprint server for biology · 2026Article
- H3T11 phosphorylation by CKII is required for heterochromatin formation in Neurospora.Nucleic acids research · 2024Article
- An ascomycete H4 variant with an unknown function.Royal Society open science · 2024Article
- The histone replacement gene His4r is involved in heat stress induced chromatin rearrangement.Scientific reports · 2021Article
- Effect of H2A.Z deletion is rescued by compensatory mutations in Fusarium graminearum.PLoS genetics · 2020Article
- The Candida albicans biofilm gene circuit modulated at the chromatin level by a recent molecular histone innovation.PLoS biology · 2019Article
- A Matter of Scale and Dimensions: Chromatin of Chromosome Landmarks in the Fungi.Microbiology spectrum · 2017Review
- Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus.Genome biology · 2017Article
- The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species.Microbiology and molecular biology reviews : MMBR · 2016Review
- The highly expressed methionine synthase gene of Neurospora crassa is positively regulated by its proximal heterochromatic region.Nucleic acids research · 2014Article
- Advances in taxonomy of genus phoma: polyphyletic nature and role of phenotypic traits and molecular systematics.Indian journal of microbiology · 2014Review
- Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-repentis, reveals transduplication and the impact of repeat elements on pathogenicity and population divergence.G3 (Bethesda, Md.) · 2013Article
- Substitutions in the amino-terminal tail of neurospora histone H3 have varied effects on DNA methylation.PLoS genetics · 2011Article
- Heterochromatin is required for normal distribution of Neurospora crassa CenH3.Molecular and cellular biology · 2011Article
- H2B- and H3-specific histone deacetylases are required for DNA methylation in Neurospora crassa.Genetics · 2010Article
- Extensive and varied modifications in histone H2B of wild-type and histone deacetylase 1 mutant Neurospora crassa.Biochemistry · 2010Article
- Protein phosphatase PP1 is required for normal DNA methylation in Neurospora.Genes & development · 2008Article
- The fungus Neurospora crassa displays telomeric silencing mediated by multiple sirtuins and by methylation of histone H3 lysine 9.Epigenetics & chromatin · 2008Article
- Global replication-independent histone H4 exchange in budding yeast.Eukaryotic cell · 2006Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have identified and characterized the complete complement of genes encoding the core histones of Neurospora crassa. In addition to the previously identified pair of genes that encode histones H3 and H4 (hH3 and hH4-1), we identified a second histone H4 gene (hH4-2), a divergently transcribed pair of genes that encode H2A and H2B (hH2A and hH2B), a homolog of the F/Z family of H2A variants (hH2Az), a homolog of the H3 variant CSE4 from Saccharomyces cerevisiae (hH3v), and a highly diverged H4 variant (hH4v) not described in other species. The hH4-1 and hH4-2 genes, which are 96% identical in their coding regions and encode identical proteins, were inactivated independently. Strains with inactivating mutations in either gene were phenotypically wild type, in terms of growth rates and fertility, but the double mutants were inviable. As expected, we were unable to isolate null alleles of hH2A, hH2B, or hH3. The genomic arrangement of the histone and histone variant genes was determined. hH2Az and the hH3-hH4-1 gene pair are on LG IIR, with hH2Az centromere-proximal to hH3-hH4-1 and hH3 centromere-proximal to hH4-1. hH3v and hH4-2 are on LG IIIR with hH3v centromere-proximal to hH4-2. hH4v is on LG IVR and the hH2A-hH2B pair is located immediately right of the LG VII centromere, with hH2A centromere-proximal to hH2B. Except for the centromere-distal gene in the pairs, all of the histone genes are transcribed toward the centromere. Phylogenetic analysis of the N. crassa histone genes places them in the Euascomycota lineage. In contrast to the general case in eukaryotes, histone genes in euascomycetes are few in number and contain introns. This may be a reflection of the evolution of the RIP (repeat-induced point mutation) and MIP (methylation induced premeiotically) processes that detect sizable duplications and silence associated genes.
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