ArticleThe Journal of physiology2002
Stimulation of pulmonary vagal C-fibres by anandamide in anaesthetized rats: role of vanilloid type 1 receptors.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Cannabidiol (CBD): Potential Use in Otorhinolaryngology.International archives of otorhinolaryngology · 2024Article
- TRP channels in airway sensory nerves.Neuroscience letters · 2021Review
- Stimulatory Effect of 5-Hydroxytryptamine (5-HT) on Rat Capsaicin-Sensitive Lung Vagal Sensory Neurons via Activation of 5-HTFrontiers in physiology · 2019Article
- Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms.Molecular metabolism · 2018Article
- Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Phrenic motor outputs in response to bronchopulmonary C-fibre activation following chronic cervical spinal cord injury.The Journal of physiology · 2016Article
- Hydrogen sulfide induces hypersensitivity of rat capsaicin-sensitive lung vagal neurons: role of TRPA1 receptors.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Proof of concept trial of dronabinol in obstructive sleep apnea.Frontiers in psychiatry · 2013Article
- Endocannabinoid CB1 receptors modulate visual output from the thalamus.Psychopharmacology · 2012Article
- Arachidonic acid products in airway nociceptor activation during acute lung injury.Experimental physiology · 2011Article
- Afferent nerves regulating the cough reflex: mechanisms and mediators of cough in disease.Otolaryngologic clinics of North America · 2010Review
- Excitation of cutaneous C nociceptors by intraplantar administration of anandamide.Brain research · 2009Article
- Sensory nerves and airway irritability.Handbook of experimental pharmacology · 2009Review
- Cough sensors. I. Physiological and pharmacological properties of the afferent nerves regulating cough.Handbook of experimental pharmacology · 2009Review
- Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat.The Journal of physiology · 2008Article
- Pain and stress in a systems perspective: reciprocal neural, endocrine, and immune interactions.The journal of pain · 2008Review
- Hypersensitivity of pulmonary chemosensitive neurons induced by activation of protease-activated receptor-2 in rats.The Journal of physiology · 2006Article
- Sensitization of pulmonary chemosensitive neurons by bombesin-like peptides in rats.American journal of physiology. Lung cellular and molecular physiology · 2005Article
- Sensory transduction of pulmonary reactive oxygen species by capsaicin-sensitive vagal lung afferent fibres in rats.The Journal of physiology · 2005Article
- 2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels.American journal of physiology. Lung cellular and molecular physiology · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This study was carried out to determine the effect of intravenous injection of anandamide on pulmonary C-fibre afferents and the cardiorespiratory reflexes. In anaesthetized, spontaneously breathing rats, intravenous bolus injection of anandamide near the right atrium immediately elicited the pulmonary chemoreflex responses, characterized by apnoea, bradycardia and hypotension. After perineural treatment of both cervical vagi with capsaicin to block the conduction of C-fibres, anandamide no longer evoked these reflex responses. In open-chest, and artificially ventilated rats, anandamide injection evoked an abrupt and intense discharge in vagal pulmonary C-fibres in a dose-dependent manner. After injection of the high dose, the fibre discharge generally started within 1 s, reached a peak in approximately 2 s, and returned to baseline within 7 s. The stimulation of C-fibres by anandamide was completely and reversibly blocked by pretreatment with capsazepine, a competitive antagonist of the vanilloid type 1 receptor. Anandamide (0.4 mg kg(-1)) stimulated approximately 93 % of pulmonary C-fibres that were activated by capsaicin at a much lower dose (0.6 microg kg(-1)); the response to anandamide showed similar intensity, but had slightly longer latency and duration than that to capsaicin. In conclusion, intravenous bolus injection of anandamide evokes a consistent and distinct stimulatory effect on pulmonary C-fibre terminals, and this effect appears to be mediated through an activation of the vanilloid type 1 receptor.
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