Evidence map›Paper›PMID 11897603›Full record

ArticleAntimicrobial agents and chemotherapy2002

Activity of BMS-284756, a novel des-fluoro(6) quinolone, against Staphylococcus aureus, including contributions of mutations to quinolone resistance.

D E Low, M Muller, C L Duncan, B M Willey, J C de Azavedo, A McGeer, B N Kreiswirth, S Pong-Porter, D J Bast

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. In vitro antibacterial activity and pharmacodynamics of new quinolones.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2003
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

D E LowDepartment of Microbiology, Toronto Medical Laboratories and Mount Sinai Hospital, Toronto, Ontario, Canada. dlow@mtsinai.on.ca
M Muller
C L Duncan
B M Willey
J C de Azavedo
A McGeer
B N Kreiswirth
S Pong-Porter
D J Bast

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The in vitro activity of BMS-284756 against 602 Staphylococcus aureus isolates, including 152 that were both methicillin and ciprofloxacin resistant (MIC > or = 4 microg/ml), was determined. For ciprofloxacin-susceptible and nonsusceptible isolates, the MICs at which 50% of organisms were inhibited were 0.015 and 2 microg/ml and the MICs at which 90% of organisms were inhibited were 0.03 and 4 microg/ml, respectively.

Indexed as

FluoroquinolonesIndolesQuinolonesAmino Acid SubstitutionAnti-Infective AgentsDNA, BacterialDNA GyraseDNA Topoisomerase IVDrug Resistance, MicrobialHumansMethicillin ResistanceMicrobial Sensitivity TestsMutationStaphylococcal InfectionsStaphylococcus aureusTopoisomerase II InhibitorsAnti-Infective AgentsDNA, BacterialDNA GyraseDNA Topoisomerase IVFluoroquinolonesgarenoxacinIndolesQuinolonesTopoisomerase II Inhibitors

Identifiers

PMID11897603
PMCPMC127112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.