ArticleOncogene2002
Coincident inactivation of 14-3-3sigma and p16INK4a is an early event in vulval squamous neoplasia.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 103 citations in OpenAlex.
- Role and clinical significance of the DNA methylation of 14-3-3σ in cancer (Review).Oncology letters · 2025Review
- Non-invasive diagnosis of vulvar dysplasia using cervical methylation markers-a case control study.BMC medicine · 2025Article
- A Computational Approach to Justifying Stratifin as a Candidate Diagnostic and Prognostic Biomarker for Pancreatic Cancer.BioMed research international · 2022Article
- Article
- Evaluation of 14-3-3 sigma as a potential partner of p16 in quiescence and differentiation.In vitro cellular & developmental biology. Animal · 2018Article
- Potential prognostic, diagnostic and therapeutic markers for human gastric cancer.World journal of gastroenterology · 2014Review
- Coexisting high-grade vulvar intraepithelial neoplasia (VIN) and condyloma acuminatum: independent lesions due to different HPV types occurring in immunocompromised patients.The American journal of surgical pathology · 2013Article
- Estimation of groin recurrence risk in patients with squamous cell vulvar carcinoma by the assessment of marker gene expression in the lymph nodes.BMC cancer · 2012Article
- Overexpression of 14-3-3σ counteracts tumorigenicity by positively regulating p73 in vivo.Oncology letters · 2011Article
- Hypomethylation of the 14-3-3σ promoter leads to increased expression in non-small cell lung cancer.Genes, chromosomes & cancer · 2011Article
- The re-infection rate of high-risk HPV and the recurrence rate of vulvar intraepithelial neoplasia (VIN) usual type after surgical treatment.Medical science monitor : international medical journal of experimental and clinical research · 2011Article
- Delineating an epigenetic continuum for initiation, transformation and progression to breast cancer.Cancers · 2011Article
- Role of 14-3-3σ in poor prognosis and in radiation and drug resistance of human pancreatic cancers.BMC cancer · 2010Article
- 14-3-3sigma, the double-edged sword of human cancers.American journal of translational research · 2009Article
- Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2.Developmental cell · 2009Article
- The 14-3-3sigma gene promoter is methylated in both human melanocytes and melanoma.BMC cancer · 2009Article
- Differential tissue-specific protein markers of vaginal carcinoma.British journal of cancer · 2009Article
- DNA hypermethylation profiles in squamous cell carcinoma of the vulva.International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2009Article
- The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas.BMC cancer · 2008Article
- Expression of 14-3-3sigma, p16 and p53 proteins in anal squamous intraepithelial neoplasm and squamous cell carcinoma.International journal of clinical and experimental pathology · 2008Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The structure and expression of 14-3-3 sigma(sigma) was analysed in squamous carcinomas (SCC) of the vulva and in the vulval pre-malignant lesion vulval intraepithelial neoplasia (VIN). Sequence analysis of the sigma coding region did not detect mutations in any case of SCC or VIN III and loss of heterozygosity (LOH) occurred in only 2 out of 27 informative cases. In contrast to the absence of genetic change, methylation-specific PCR (MSP) analysis revealed dense CpG methylation within the sigma gene in approximately 60% of cases of vulval SCC, but methylation was not detected in matched, normal epithelial tissue. Methylation was associated in all cases with reduced or absent expression of sigma mRNA. There was no correlation between sigma methylation and HPV or p53 status. Analysis of pre-malignant vulval intraepithelial neoplasia (VIN) revealed that sigma methylation was detectable early in neoplastic development. Co-incident methylation, accompanied by loss of expression, of sigma and p16INK4a was commonly detected in both SCC and VIN III, suggesting that epigenetic silencing of these two genes is an early and important event in vulval neoplasia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.