ArticleOncogene2002
Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 64 citations in OpenAlex.
- RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease.Cancer discovery · 2021Article
- Article
- Id-1 promotes migration and invasion of non-small cell lung cancer cells through activating NF-κB signaling pathway.Journal of biomedical science · 2017Article
- Regulation of AURKC expression by CpG island methylation in human cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Genetic polymorphisms in the vitamin D pathway in relation to lung cancer risk and survival.Oncotarget · 2015Article
- Basic helix loop helix (bHLH) transcription factor 3 (TCF3, E2A) is regulated by androgens in prostate cancer cells.American journal of cancer research · 2015Article
- ID1 promotes breast cancer metastasis by S100A9 regulation.Molecular cancer research : MCR · 2014Article
- Serum regulation of Id1 expression by a BMP pathway and BMP responsive element.Biochimica et biophysica acta · 2013Article
- Stiff collagen matrices increase tumorigenic prolactin signaling in breast cancer cells.The Journal of biological chemistry · 2013Article
- Auto-activation of c-JUN gene by amino acid deprivation of hepatocellular carcinoma cells reveals a novel c-JUN-mediated signaling pathway.The Journal of biological chemistry · 2011Article
- Cyclin D1, Id1 and EMT in breast cancer.BMC cancer · 2011Article
- ID1 facilitates the growth and metastasis of non-small cell lung cancer in response to nicotinic acetylcholine receptor and epidermal growth factor receptor signaling.Molecular and cellular biology · 2011Article
- A genetic strategy for combined screening and localized imaging of breast cancer.Molecular imaging and biology · 2011Article
- Expression of Id-1 is regulated by MCAM/MUC18: a missing link in melanoma progression.Cancer research · 2011Article
- Id1 enhances RING1b E3 ubiquitin ligase activity through the Mel-18/Bmi-1 polycomb group complex.Oncogene · 2010Article
- Expression of the inhibitor of DNA-binding (ID)-1 protein as an angiogenic mediator in tumour advancement of uterine cervical cancers.British journal of cancer · 2008Article
- Induction of ID1 expression and apoptosis by the histone deacetylase inhibitor (trichostatin A) in human acute myeloid leukaemic cells.Cell proliferation · 2008Article
- Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer.Oncogene · 2005Article
- Overexpression of Id-1 is significantly associated with tumour angiogenesis in human pancreas cancers.British journal of cancer · 2004Article
- Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The helix-loop-helix protein Id-1 is a dominant negative regulator of basic helix-loop-helix transcription factors, and plays a key role in the control of breast epithelial cell growth, invasion and differentiation. Previous investigations in our laboratory have shown that Id-1 mRNA was constitutively expressed in highly aggressive and invasive human breast cancer cells in comparison to non-transformed or non-aggressive cancerous cells, and that this loss of regulation is mediated by a 2.2-kb region of the human Id-1 promoter. Here we show that a 31 bp sequence within this 2.2-kb promoter, located 200 bp upstream of the initiation of transcription, is responsible for the constitutive expression of Id-1 in metastatic human breast cancer cells. Using gel shift experiments, we identified a high molecular weight complex present only in non-aggressive breast cancer cells cultured in serum-free medium and which appear to be necessary for proper Id-1 repression. In contrast, nuclear extracts from highly aggressive and metastatic cell lines do not contain this large molecular weight complex. Using DNA affinity precipitation assays (DAPA), we show that this complex contains SP-1, NF-1, Rb and HDAC-1 proteins. On the basis of these findings, we propose a mechanism for the loss of regulation of Id-1 promoter in invasive and metastatic human breast cancer cells.
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