ArticleOncogene2002
Activation of STAT5 triggers proliferation and contributes to anti-apoptotic signalling mediated by the oncogenic Xmrk kinase.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Curcumin protects extracellular matrix to maintain microenvironmental stability inhibiting colon cancer metastasis through HPSE/IL-6/STAT5 axis.Die Naturwissenschaften · 2025Article
- Segregation Between an Ornamental and a Disease Driver Gene Provides Insights Into Pigment Cell Regulation.Pigment cell & melanoma research · 2025Article
- Transcriptional background effects on a tumor driver gene in different pigment cell types of medaka.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Article
- Validity of Xiphophorus fish as models for human disease.Disease models & mechanisms · 2024Review
- Xmrks the Spot: Fish Models for Investigating Epidermal Growth Factor Receptor Signaling in Cancer Research.Cells · 2021Review
- Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy.Signal transduction and targeted therapy · 2021Review
- Spontaneously occurring melanoma in animals and their relevance to human melanoma.The Journal of pathology · 2020Review
- Balancing STAT Activity as a Therapeutic Strategy.Cancers · 2019Review
- Application of the Transcriptional Disease Signature (TDSs) to Screen Melanoma-Effective Compounds in a Small Fish Model.Scientific reports · 2019Article
- The Power of Fish Models to Elucidate Skin Cancer Pathogenesis and Impact the Discovery of New Therapeutic Opportunities.International journal of molecular sciences · 2018Review
- Comparison of Xiphophorus and human melanoma transcriptomes reveals conserved pathway interactions.Pigment cell & melanoma research · 2018Article
- Transcriptional control analyses of the Xiphophorus melanoma oncogene.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015Article
- Whole Body Melanoma Transcriptome Response in Medaka.PloS one · 2015Article
- Beyond the zebrafish: diverse fish species for modeling human disease.Disease models & mechanisms · 2014Review
- Tuning of alternative splicing--switch from proto-oncogene to tumor suppressor.International journal of biological sciences · 2013Article
- JunD/AP-1-mediated gene expression promotes lymphocyte growth dependent on interleukin-7 signal transduction.PloS one · 2012Article
- Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension.Circulation · 2011Article
- Gene expression analysis after receptor tyrosine kinase activation reveals new potential melanoma proteins.BMC cancer · 2010Article
- Genetic and environmental melanoma models in fish.Pigment cell & melanoma research · 2010Review
- In vivo identification of novel STAT5 target genes.Nucleic acids research · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extensive studies of primary tumors and tumor derived cell lines revealed that inappropriate activation of specific STATs (particularly of STAT3 and STAT5) occurs with high frequency in a wide variety of human cancers. We reported recently that the melanoma inducing EGFR-related receptor Xmrk specifically induces constitutive activation of STAT5 in fish melanoma cells. However, little is known about the role of STAT5 in solid tumours in general and its function in melanoma in particular. Recent examinations suggest that activated STAT signalling participates in oncogenesis by stimulating cell proliferation and preventing apoptosis. As an initial approach to understanding the consequences of Xmrk induced STAT5 signalling we used the well characterized pro B-cell line Ba/F3 as a sensitive system to analyse mitogenic as well as anti-apoptotic signalling. We identified STAT5 activation as being involved in both growth and survival signalling triggered by the Xmrk kinase possibly due to STAT5 induced expression of pim-1 and bcl-x. We also found a new mechanism of activation of STAT5 by receptor tyrosine kinases, whereby direct interaction of the receptor kinase domain with the STAT protein in a phosphotyrosine independent way led to activation of STAT5 in terms of DNA binding and target gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.