ArticleOncogene2002
Thioredoxin post-transcriptional regulation by H19 provides a new function to mRNA-like non-coding RNA.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Therapeutic modulation of HIV-1 using miRNAs and lncRNAs: from bench to bedside.Virology journal · 2026Review
- LncRNA H19 Activates the RAS-MAPK Signaling Pathway via miR-140-5p/SOS1 Axis in Malignant Liver Tumors.Current medical science · 2024Article
- Article
- A guide to naming human non-coding RNA genes.The EMBO journal · 2020Review
- The Roles of H19 in Regulating Inflammation and Aging.Frontiers in immunology · 2020Review
- Increased Extracellular Matrix Protein Production in Chronic Diabetic Complications: Implications of Non-Coding RNAs.Non-coding RNA · 2019Review
- The H19 Long non-coding RNA in cancer initiation, progression and metastasis - a proposed unifying theory.Molecular cancer · 2015Review
- Lentivirus-mediated RNA interference targeting the H19 gene inhibits cell proliferation and apoptosis in human choriocarcinoma cell line JAR.BMC cell biology · 2013Article
- Non-coding RNA and antisense RNA. Nature's trash or treasure?Biochimie · 2011Review
- Large non-coding RNAs: missing links in cancer?Human molecular genetics · 2010Review
- Primate-specific spliced PMCHL RNAs are non-protein coding in human and macaque tissues.BMC evolutionary biology · 2008Article
- A novel H19 antisense RNA overexpressed in breast cancer contributes to paternal IGF2 expression.Molecular and cellular biology · 2008Article
- The H19 non-coding RNA is essential for human tumor growth.PloS one · 2007Article
- Riboregulator H19 induction of MDR1-associated drug resistance in human hepatocellular carcinoma cells.Oncogene · 2007Article
- Application of proteomics in the study of tumor metastasis.Genomics, proteomics & bioinformatics · 2004Review
- Functional proteomics of breast cancer for signal pathway profiling and target discovery.Journal of mammary gland biology and neoplasia · 2002Review
- Turnover of primary transcripts is a major step in the regulation of mouse H19 gene expression.EMBO reports · 2002Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classically, the functional product of coding genes is a protein whose synthesis is directed by an mRNA-template. However, in the last few years several genes yielding an mRNA-like non-coding RNA as a functional product have been identified. In most cases these transcripts are synthesized by the RNA polymerase II, capped, spliced and polyadenylated, like classical mRNA. These latter have non-conserved open reading frames and seem to be untranslated. Consequently, it has been proposed and admitted that these genes act at the RNA level, and are so-called 'riboregulators'. H19 belongs to this class of gene and its role remains a matter of debate: for some authors it is an oncogene, for others a tumour suppressor. Here, we demonstrate, using a proteomic approach, that an H19 overexpression in human cancerous mammary epithelial cells stably transfected with genomic DNA containing the entire H19 gene is responsible for positively regulating at the post-transcriptional level the thioredoxin, a key protein of the cellular redox metabolism. Interestingly, this protein accumulates in many cancerous tissues, such as breast carcinomas in which we have also demonstrated an overexpression of the H19 gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.