ArticleOncogene2002
Bcl-2 expression delays hepatocyte cell cycle progression during liver regeneration.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Reducing Bias in Mass Cytometry Data through Corrections for Spillover and Nonspecific Binding.Analytical chemistry · 2026Article
- OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-κB Signaling.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation.Cellular & molecular immunology · 2019Article
- Identification of a Novel OX40LScientific reports · 2018Article
- Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation.Cell death and differentiation · 2015Article
- Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase.Cancer research · 2014Article
- Initiation of premature senescence by Bcl-2 in hypoxic condition.International journal of clinical and experimental pathology · 2014Article
- Rejuvenating Bi(d)ology.Oncogene · 2013Review
- Mitochondrial calcium regulates rat liver regeneration through the modulation of apoptosis.Hepatology (Baltimore, Md.) · 2011Article
- c-Myc induction of programmed cell death may contribute to carcinogenesis: a perspective inspired by several concepts of chemical carcinogenesis.Cancer biology & therapy · 2011Review
- Bid agonist regulates murine hepatocyte proliferation by controlling endoplasmic reticulum calcium homeostasis.Hepatology (Baltimore, Md.) · 2010Article
- The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers.Hepatology (Baltimore, Md.) · 2009Article
- DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis.Journal of Zhejiang University. Science. B · 2007Review
- Bid-independent mitochondrial activation in tumor necrosis factor alpha-induced apoptosis and liver injury.Molecular and cellular biology · 2007Article
- Deletion of Bid impedes cell proliferation and hepatic carcinogenesis.The American journal of pathology · 2005Article
- Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry.The EMBO journal · 2003Article
- Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy.The Journal of clinical investigation · 2002Article
- Bcl-2 expression inhibits liver carcinogenesis and delays the development of proliferating foci.The American journal of pathology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Bcl-2 is the prototype of a family of genes that prevent apoptosis. However, several reports indicate that Bcl-2 may also act as a cell cycle modulator. In several human tumors, Bcl-2 expression correlates with a more favorable prognosis and lower tumor proliferative activity. We have shown that Bcl-2 expression delays liver tumor development in transgenic mice even when the gene is turned on shortly before the time of tumor development. We hypothesized that Bcl-2 may delay liver tumorigenesis by interfering with hepatocyte proliferation. To test whether Bcl-2 expression may act on hepatocyte replication we studied liver regeneration in Bcl-2 transgenic mice and wild-type littermates. DNA replication was delayed by approximately 8 h in Bcl-2 transgenic mice compared to the timing of the response in wild-type littermates. Cyclin D expression showed no alterations in the regenerating liver of Bcl-2 transgenic mice. In contrast, there was a delay in the expression of p107, cyclin E and in the activity of cyclin E/cdk 2 activity. These results show that Bcl-2 expression delays cell cycle progression in hepatocytes and suggests that it acts at a step involving cyclin E and p107.
Indexed as
Identifiers
11896583What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.