ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Serotonin release evoked by tail nerve stimulation in the CNS of aplysia: characterization and relationship to heterosynaptic plasticity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
What it found
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Who cites it
83 citing papers in PubMed, 175 citations in OpenAlex.
- Copper Homeostasis and Cuproptosis in Neurological Disorders.Drug design, development and therapy · 2026Review
- Ephaptic conduction molding memory engrams.BMC biology · 2025Article
- Serotonergic modulation of swallowing in a complete fly vagus nerve connectome.Current biology : CB · 2024Article
- Role of serotonin in the lack of sensitization caused by prolonged food deprivation in Aplysia.Behavioural brain research · 2024Article
- Pattern detection in the TGFβ cascade controls the induction of long-term synaptic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Copper Induces Cognitive Impairment in Mice via Modulation of Cuproptosis and CREB Signaling.Nutrients · 2023Article
- Precise timing of ERK phosphorylation/dephosphorylation determines the outcome of trial repetition during long-term memory formation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- ELAV Proteins Bind and Stabilize C/EBP mRNA in the Induction of Long-Term Memory inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Neurotropic and modulatory effects of insulin-like growth factor II in Aplysia.Scientific reports · 2019Article
- Transcriptional changes before and after forgetting of a long-term sensitization memory in Aplysia californica.Neurobiology of learning and memory · 2018Article
- Effects of internal and external factors on the budgeting between defensive and non-defensive responses in Aplysia.Behavioural brain research · 2018Article
- The CaScientific reports · 2018Article
- The selective serotonin reuptake inhibitor fluoxetine increases spontaneous afferent firing, but not mechanonociceptive sensitization, in octopus.Invertebrate neuroscience : IN · 2017Article
- Toward a multiscale modeling framework for understanding serotonergic function.Journal of psychopharmacology (Oxford, England) · 2017Review
- A novel in vitro analog expressing learning-induced cellular correlates in distinct neural circuits.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Transforming growth factor β recruits persistent MAPK signaling to regulate long-term memory consolidation in Aplysia californica.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Investigating the Potential Signaling Pathways That Regulate Activation of the Novel PKC Downstream of Serotonin in Aplysia.PloS one · 2016Article
- The Contribution of Spatial and Temporal Molecular Networks in the Induction of Long-term Memory and Its Underlying Synaptic Plasticity.AIMS neuroscience · 2016Article
- Structural Components of Synaptic Plasticity and Memory Consolidation.Cold Spring Harbor perspectives in biology · 2015Review
- Article
23 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Considerable experimental evidence suggests that serotonin (5-HT) at sensory neuron-->motor neuron (SN-->MN) synapses, as well as other neuronal sites, contributes importantly to simple forms of learning such as sensitization and classical conditioning in Aplysia. However, the actual release of 5-HT in the CNS induced by sensitizing stimuli such as tail shock has not been directly demonstrated. In this study, we addressed this question by (1) immunohistochemically labeling central 5-HT processes and (2) directly measuring with chronoamperometry the release of 5-HT induced by pedal tail nerve (P9) shock onto tail SNs in the pleural ganglion and their synapses onto tail MNs in the pedal ganglion. We found that numerous 5-HT-immunoreactive fibers surround both the SN cell bodies in the pleural ganglion and SN axons in the pedal ganglion. Chronoamperometric detection of 5-HT performed with carbon fiber electrodes implanted in the vicinity of tail SN somata and synapses revealed an electrochemical 5-HT signal lasting approximately 40 sec after a brief shock of P9. 5-HT release was restricted to discrete subregions (modulatory fields) of the CNS, including the vicinity of tail SN soma and synapses ipsilateral to the stimulation. Increasing P9 shock frequency augmented the amplitude of the 5-HT signal and, in parallel, increased SN excitability and SN synaptic transmission onto tail MNs. However, the relationship between the amount of 5-HT release and the two forms of SN plasticity was not uniform: SN excitability increased in a graded manner with increased 5-HT release, whereas synaptic facilitation exhibited a highly nonlinear relationship. The development of chronoamperometric techniques in Aplysia now paves the way for a more complete understanding of the contribution of the serotonergic modulatory pathway to memory processing in this system.
Indexed as
Identifiers
11896169PMC6758260W2113594310What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.