ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Neuregulin expression at neuromuscular synapses is modulated by synaptic activity and neurotrophic factors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
40 citing papers in PubMed, 88 citations in OpenAlex.
- Short-term exposure to an obesogenic diet during adolescence elicits anxiety-related behavior and neuroinflammation: modulatory effects of exogenous neuregulin-1.Translational psychiatry · 2022Article
- Completion of neuronal remodeling prompts myelination along developing motor axon branches.The Journal of cell biology · 2021Article
- Specific Expression of Glial-Derived Neurotrophic Factor in Muscles as Gene Therapy Strategy for Amyotrophic Lateral Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Developmental neuromuscular synapse elimination: Activity-dependence and potential downstream effector mechanisms.Neuroscience letters · 2020Review
- Impaired Expression of Neuregulin 1 and Nicotinic Acetylcholine Receptor β4 Subunit in Diverticular Disease.Frontiers in cellular neuroscience · 2019Article
- Schwann cells participate in synapse elimination at the developing neuromuscular junction.Current opinion in neurobiology · 2017Review
- Neuregulin1 fine-tunes pre-, post-, and perisynaptic neuromuscular junction development.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development.Frontiers in molecular neuroscience · 2017Review
- Improvement of Eye Alignment in Adult Strabismic Monkeys by Sustained IGF-1 Treatment.Investigative ophthalmology & visual science · 2016Article
- Article
- Neuregulin1 displayed on motor axons regulates terminal Schwann cell-mediated synapse elimination at developing neuromuscular junctions.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Rapid transient isoform-specific neuregulin1 transcription in motor neurons is regulated by neurotrophic factors and axon-target interactions.Molecular and cellular neurosciences · 2015Article
- Adaptation of slow myofibers: the effect of sustained BDNF treatment of extraocular muscles in infant nonhuman primates.Investigative ophthalmology & visual science · 2015Article
- Expression and function of Neuregulin 1 and its signaling system ERBB2/3 in the enteric nervous system.Frontiers in cellular neuroscience · 2015Article
- Complexity of trophic factor signaling in experimental autoimmune encephalomyelitis: differential expression of neurotrophic and gliotrophic factors.Journal of neuroimmunology · 2013Article
- Differential effects of RET and TRKB on axonal branching and survival of parasympathetic neurons.Developmental neurobiology · 2013Article
- Respiratory muscle plasticity.Comprehensive Physiology · 2012Review
- Aberrant neuregulin 1 signaling in amyotrophic lateral sclerosis.Journal of neuropathology and experimental neurology · 2012Article
- Critical period of axoglial signaling between neuregulin-1 and brain-derived neurotrophic factor required for early Schwann cell survival and differentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Neuregulin-1 at synapses on phrenic motoneurons.The Journal of comparative neurology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The proper formation of neuromuscular synapses requires ongoing synaptic activity that is translated into complex structural changes to produce functional synapses. One mechanism by which activity could be converted into these structural changes is through the regulated expression of specific synaptic regulatory factors. Here we demonstrate that blocking synaptic activity with curare reduces synaptic neuregulin expression in a dose-dependent manner yet has little effect on synaptic agrin or a muscle-derived heparan sulfate proteoglycan. These changes are associated with a fourfold increase in number and a twofold reduction in average size of synaptic acetylcholine receptor clusters that appears to be caused by excessive axonal sprouting with the formation of new, smaller acetylcholine receptor clusters. Activity blockade also leads to threefold reductions in brain-derived neurotrophic factor and neurotrophin 3 expression in muscle without appreciably changing the expression of these same factors in spinal cord. Adding back these or other neurotrophic factors restores synaptic neuregulin expression and maintains normal end plate band architecture in the presence of activity blockade. The expression of neuregulin protein at synapses is independent of spinal cord and muscle neuregulin mRNA levels, suggesting that neuregulin accumulation at synapses is independent of transcription. These findings suggest a local, positive feedback loop between synaptic regulatory factors that translates activity into structural changes at neuromuscular synapses.
Indexed as
Identifiers
11896160PMC6758272W1563468725What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.