ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Alternative splicing unmasks dendritic and axonal targeting signals in metabotropic glutamate receptor 1.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 85 citations in OpenAlex.
- Parvalbumin interneuron mGluNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Parvalbumin interneuron mGlubioRxiv : the preprint server for biology · 2024Article
- Subsynaptic mobility of presynaptic mGluR types is differentially regulated by intra- and extracellular interactions.Molecular biology of the cell · 2022Article
- Disparate Regulatory Mechanisms Control Fat3 and P75NTR Protein Transport through a Conserved Kif5-Interaction Domain.PloS one · 2016Article
- Actinin-4 Governs Dendritic Spine Dynamics and Promotes Their Remodeling by Metabotropic Glutamate Receptors.The Journal of biological chemistry · 2015Article
- Metabotropic glutamate receptor 1 splice variants mGluR1a and mGluR1b combine in mGluR1a/b dimers in vivo.Neuropharmacology · 2014Article
- The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Primary cilia and dendritic spines: different but similar signaling compartments.Molecules and cells · 2013Review
- Apical targeting of the P2Y(4) receptor is directed by hydrophobic and basic residues in the cytoplasmic tail.American journal of physiology. Cell physiology · 2013Article
- Somato-dendritic localization and signaling by leptin receptors in hypothalamic POMC and AgRP neurons.PloS one · 2013Article
- Autosomal-recessive congenital cerebellar ataxia is caused by mutations in metabotropic glutamate receptor 1.American journal of human genetics · 2012Article
- Dileucine and PDZ-binding motifs mediate synaptic adhesion-like molecule 1 (SALM1) trafficking in hippocampal neurons.The Journal of biological chemistry · 2012Article
- Mechanisms of polarized membrane trafficking in neurons -- focusing in on endosomes.Molecular and cellular neurosciences · 2011Review
- Article
- The Sushi domains of GABAB receptors function as axonal targeting signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Alternative splicing of G protein-coupled receptors: physiology and pathophysiology.Cellular and molecular life sciences : CMLS · 2009Review
- Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Proteomic analysis reveals novel binding partners of metabotropic glutamate receptor 1.Journal of neurochemistry · 2009Article
- Developmental regulation of metabotropic glutamate receptor 1 splice variants in olfactory bulb mitral cells.Journal of neuroscience research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Precise targeting of neurotransmitter receptors to different neuronal compartments is a fundamental step for the establishment and function of synaptic circuitry. Group I metabotropic glutamate receptors, mGluR1 and mGluR5, control glutamatergic neurotransmission by acting both postsynaptically and presynaptically. Four alternatively spliced variants of the mGluR1 gene exist, which differ in their signaling properties and subcellular localization. The present study was undertaken to identify the molecular signals responsible for trafficking of these receptors to different neuronal compartments. Here we report that targeting of mGluR1 to dendrites and axons of transfected retina neurons is controlled by alternative splicing. We have identified in the tail of the receptor a tripeptide motif, which is necessary and sufficient to exclude the splice variant mGluR1b from distal dendrites and to drive it to the axon. This motif, which is present in all the mGluR1 receptors, is masked in mGluR1a by a dominant dendritic signal sequence harbored by the extended C-terminal tail of this splice variant. Furthermore, we show that the identified axonal and dendritic targeting signals are also necessary and sufficient to localize mGluR1b and mGluR1a to the apical and basolateral compartment of Madin-Darby canine kidney cells, respectively, consistent with the existence of common trafficking components for polarized targeting in epithelial cells and neurons.
Indexed as
Identifiers
11896159PMC6758268W1516142101What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.