ArticleJournal of clinical pathology2002
Intermediate grade osteosarcoma and chondrosarcoma arising in an osteochondroma. A case report of a patient with hereditary multiple exostoses.
Article in Journal of clinical pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 55 citations in OpenAlex.
- Malignancy Ratio in Pediatric Patients with Hereditary Multiple Exostoses: True Association or Reporting Bias?Pediatric reports · 2025Article
- Histopathological features of condylar hyperplasia and condylar Osteochondroma: a comparison study.Orphanet journal of rare diseases · 2019Article
- Osteochondroma of the coronoid process: A case report and review of the literature.Oncology letters · 2019Article
- Osteoblastic Osteosarcoma Arising beneath an Osteochondroma in an 11-Year-Old Male with Multiple Hereditary Exostoses.Case reports in orthopedics · 2018Article
- Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice.PLoS genetics · 2017Article
- Multiple osteochondromas of the antlers and cranium in a free-ranging white-tailed deer (Odocoileus virginianus).PloS one · 2017Article
- Secondary osteosarcoma arising from osteochondroma following autologous stem cell transplantation with total-body irradiation for neuroblastoma: A case report.Oncology letters · 2015Article
- Usage of a curved chisel when resecting osteochondroma in the long bone.Clinics in orthopedic surgery · 2013Article
- Multiple osteochondromas.Orphanet journal of rare diseases · 2008Review
- Premalignant conditions of bone.Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2006Review
- Multiple osteochondromas: clinicopathological and genetic spectrum and suggestions for clinical management.Hereditary cancer in clinical practice · 2004Article
- Osteosarcoma Arising from Iliac Bone Lesions of Hereditary Multiple Osteochondromas: A Case Report.Case reports in oncologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 40 year old man with hereditary multiple exostoses (HME), affecting predominantly his left proximal tibia, distal femur, and proximal femur, underwent resection of an osteochondroma near the trochanter major of his left proximal femur because of malignant transformation of the cartilaginous cap towards secondary peripheral chondrosarcoma. The patient had a history of a papillary thyroid carcinoma four years previously. At examination of the resected specimen, a third malignant tumour, an intermediate grade osteosarcoma (grade II/IV), was found in the osseous stalk of the osteochondroma. Although no mutations were found in the EXT1 and EXT2 genes, the genes involved in HME, or in exons 5-8 of the p53 gene, the development of three malignancies before the age of 40 suggests that this patient is genetically prone to malignant transformation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.