ArticleInfection and immunity2002
Lipoteichoic acids from Lactobacillus johnsonii strain La1 and Lactobacillus acidophilus strain La10 antagonize the responsiveness of human intestinal epithelial HT29 cells to lipopolysaccharide and gram-negative bacteria.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 123 citations in OpenAlex.
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- Unveiling the potential ofFrontiers in microbiology · 2025Review
- Probiotic Strain Limosilactobacillus reuteri 29B is Proven Safe and Exhibits Potential Probiotic Traits in a Murine Vaginal Model.Probiotics and antimicrobial proteins · 2024Article
- Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases.Foods (Basel, Switzerland) · 2023Review
- Recombinant p40 Protein Promotes Expression of Occludin in HaCaT Keratinocytes: A Brief Communication.Microorganisms · 2023Article
- Use of Postbiotic as Growth Promoter in Poultry Industry: A Review of Current Knowledge and Future Prospects.Food science of animal resources · 2023Review
- Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injuryActa pharmaceutica Sinica. B · 2023Article
- Postbiotics: Current Trends in Food and Pharmaceutical Industry.Foods (Basel, Switzerland) · 2022Review
- The effect of a postbiotic produced by stabilized non-viable Lactobacilli on the health, growth performance, immunity, and gut status of colisepticaemic broiler chickens.Tropical animal health and production · 2022Article
- Current postbiotics in the cosmetic market-an update and development opportunities.Applied microbiology and biotechnology · 2022Review
- Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health.Microbial cell factories · 2020Review
- Paraprobiotics and postbiotics: Contemporary and promising natural antibiotics alternatives and their applications in the poultry field.Open veterinary journal · 2020Review
- In Silico Prediction and In Vitro Assessment of Multifunctional Properties of Postbiotics Obtained From Two Probiotic Bacteria.Probiotics and antimicrobial proteins · 2020Article
- Paraprobiotics and Postbiotics of ProbioticFrontiers in nutrition · 2020Review
- Suppression of Intestinal Epithelial Cell Chemokine Production byFrontiers in immunology · 2018Article
- The Effect ofOsong public health and research perspectives · 2017Article
- Bile-Salt-Hydrolases from the Probiotic StrainFrontiers in microbiology · 2017Article
- Immunomodulatory activity of two potential probiotic strains in LPS-stimulated HT-29 cells.Genes & nutrition · 2014Article
- The role of cell surface architecture of lactobacilli in host-microbe interactions in the gastrointestinal tract.Mediators of inflammation · 2013Review
- Immunoregulatory potential of exopolysaccharide from Lactobacillus rhamnosus KL37: effects on the production of inflammatory mediators by mouse macrophages.International journal of experimental pathology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal epithelial cells (IECs) respond to lipopolysaccharide (LPS) from gram-negative bacteria in the presence of the soluble form of CD14 (sCD14), a major endotoxin receptor. Since sCD14 is also known to interact with gram-positive bacteria and their components, we looked at whether sCD14 could mediate their effects on human IECs. To this end, we examined the production of proinflammatory cytokines following exposure of the IECs to specific gram-positive bacteria or their lipoteichoic acids (LTAs) in the absence and presence of human milk as a source of sCD14. In contrast to LPS from Escherichia coli or Salmonella enteritidis, neither the gram-positive bacteria Lactobacillus johnsonii strain La1 and Lactobacillus acidophilus strain La10 nor their LTAs stimulated IECs, even in the presence of sCD14. However, both LTAs inhibited the sCD14-mediated LPS responsiveness of IECs. We have previously hypothesized that sCD14 in human milk is a means by which the neonate gauges the bacterial load in the intestinal lumen and liberates protective proinflammatory cytokines from IECs. The present observations suggest that gram-positive organisms, via their LTAs, temper this response and prevent an exaggerated inflammatory response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.