ArticleClinical cancer research : an official journal of the American Association for Cancer Research2002
Autoimmunity to the M(r) 32,000 subunit of replication protein A in breast cancer.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Can serum autoantibodies be a potential early detection biomarker for breast cancer in women? A diagnostic test accuracy review and meta-analysis.Systematic reviews · 2022Pooled it
- Menin in Cancer.Genes · 2024Review
- Proper RPA acetylation promotes accurate DNA replication and repair.Nucleic acids research · 2023Article
- Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers.NPJ breast cancer · 2023Article
- Non-coding regions of nuclear-DNA-encoded mitochondrial genes and intergenic sequences are targeted by autoantibodies in breast cancer.Frontiers in genetics · 2022Article
- Rtt105 promotes high-fidelity DNA replication and repair by regulating the single-stranded DNA-binding factor RPA.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Replication Protein A (RPA) Mediates Radio-Resistance of Glioblastoma Cancer Stem-Like Cells.International journal of molecular sciences · 2020Article
- Multiplexed Autoantibody Signature for Serological Detection of Canine Mammary Tumours.Scientific reports · 2018Article
- Elevated Expression of RPA3 Is Involved in Gastric Cancer Tumorigenesis and Associated with Poor Patient Survival.Digestive diseases and sciences · 2017Article
- Serum APE1 as a predictive marker for platinum-based chemotherapy of non-small cell lung cancer patients.Oncotarget · 2016Article
- Cdc45 is limiting for replication initiation in humans.Cell cycle (Georgetown, Tex.) · 2016Article
- Autoantibodies in breast cancer sera are not epiphenomena and may participate in carcinogenesis.BMC cancer · 2015Article
- Latest updates on antiretinal autoantibodies associated with vision loss and breast cancer.Investigative ophthalmology & visual science · 2015Article
- A tight control of Rif1 by Oct4 and Smad3 is critical for mouse embryonic stem cell stability.Cell death & disease · 2015Article
- Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer.Biochemical pharmacology · 2015Article
- Humoral autoimmune responses to insulin-like growth factor II mRNA-binding proteins IMP1 and p62/IMP2 in ovarian cancer.Journal of immunology research · 2014Article
- Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising.Frontiers in oncology · 2014Review
- An Antibody-based Blood Test Utilizing a Panel of Biomarkers as a New Method for Improved Breast Cancer Diagnosis.Biomarkers in cancer · 2013Article
- Repair-specific functions of replication protein A.The Journal of biological chemistry · 2012Article
- Serologic laboratory findings in malignancy.Rheumatic diseases clinics of North America · 2011Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
purposeWe sought to identify autoantigens recognized by antibodies in breast cancer patient sera with potential diagnostic or prognostic significance. EXPERIMENTAL
designSerum from a female breast cancer patient exhibiting a high titer antinuclear antibody was used to screen a HeLa cDNA expression library, leading to the cloning of a cDNA for the M(r) 32,000 subunit of replication protein A (RPA32). RPA32 expression and localization were assayed in autologous tumor by monoclonal antibody staining. A specific ELISA using recombinant protein was used to screen sera from 801 breast cancer patients and 65 controls.
resultsA relationship between anti-replication protein A (RPA) antibodies and the ductal breast carcinoma of the proband was suggested by overexpression and aberrant localization of RPA32 in tumor cells as compared with surrounding normal ductal tissue and by the presence of anti-RPA32 antibodies before the diagnosis. The prevalence of anti-RPA32 antibodies was significantly higher (P < 0.01) among breast cancer patients (87 of 801 patients) than among noncancer controls (0 of 65 controls). Similarly, anti-RPA32 antibodies were present in 4 of 39 patients with intraductal in situ carcinoma. No associations were found between anti-RPA antibodies and survival, occurrence of a second tumor, metastases, or antibodies to p53. Reactivity to RPA32 also was detected in sera from 3 of 47 patients with other cancers.
conclusionsIn view of the central role of RPA in DNA replication, recombination, and repair, we suggest that autoimmunity to RPA32 may reflect molecular changes involved in the process of tumorigenesis. The finding of antibodies to RPA32 before diagnosis and their prevalence in in situ carcinoma suggest that they are potentially useful markers of early disease.
Indexed as
Identifiers
11895905PMC5604237W1905950615What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.