ArticleAmerican journal of human genetics2002
Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed, 120 citations in OpenAlex.
- Adaptive evolution and functional significance of theEcology and evolution · 2024Article
- Association of CAPN10 gene (rs3842570) polymorphism with the type 2 diabetes mellitus among the population of Noakhali region in Bangladesh: a case-control study.Genomics & informatics · 2023Article
- Identifying Genomic Signatures of Positive Selection to Predict Protective Genomic Loci in the Cohort of Lithuanian Clean-Up Workers of the Chornobyl Nuclear Disaster.Current issues in molecular biology · 2023Article
- Genetic signature of strong recent positive selection at interleukin-32 gene in goat.Asian-Australasian journal of animal sciences · 2017Article
- Positive selection of IL-33 in adaptive immunity of domestic Chinese goats.Ecology and evolution · 2017Article
- Finding the Genomic Basis of Local Adaptation: Pitfalls, Practical Solutions, and Future Directions.The American naturalist · 2016Review
- Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Extensive genomic variability of knops blood group polymorphisms is associated with sickle cell disease in Africa.Evolutionary bioinformatics online · 2015Article
- Article
- Investigation of Calpain 10 (rs2975760) gene polymorphism in Asian Indians with Gestational Diabetes Mellitus.Meta gene · 2014Article
- Common polymorphisms of calpain-10 and the risk of polycystic ovary syndrome in Tunisian population: a case-control study.Molecular biology reports · 2014Article
- Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia.European journal of human genetics : EJHG · 2013Article
- Recent human evolution has shaped geographical differences in susceptibility to disease.BMC genomics · 2011Article
- Has human evolution stopped?Rambam Maimonides medical journal · 2010Article
- Common polymorphisms of calpain-10 and the risk of Type 2 Diabetes in a Tunisian Arab population: a case-control study.BMC medical genetics · 2010Article
- Genome-wide scans for footprints of natural selection.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Linkage disequilibrium and population structure in wild and domesticated populations of Phaseolus vulgaris L.Evolutionary applications · 2009Article
- Molecular population genetics of human CYP3A locus: signatures of positive selection and implications for evolutionary environmental medicine.Environmental health perspectives · 2009Article
- The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population.PloS one · 2008Article
- Worldwide population differentiation at disease-associated SNPs.BMC medical genomics · 2008Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Recently, a positional cloning study proposed that haplotypes at the calpain-10 locus (CAPN10) are associated with increased risk of type 2 diabetes, or non-insulin-dependent diabetes mellitus, in Mexican Americans, Finns, and Germans. To inform the interpretation of the original mapping results and to look for evidence for the action of natural selection on CAPN10, we undertook a population-based genotyping survey of the candidate susceptibility variants. First, we genotyped sites 43, 19, and 63 (the haplotype-defining variants previously proposed) and four closely linked SNPs, in 561 individuals from 11 populations from five continents, and we examined the linkage disequilibrium among them. We then examined the ancestral state of these sites by sequencing orthologous portions of CAPN10 in chimpanzee and orangutan (the identity of sites 43 and 19 was further investigated in a limited sample of other great apes and Old World and New World monkeys). Our survey suggests larger-than-expected differences in the distribution of CAPN10 susceptibility variants between African and non-African populations, with common, derived haplotypes in European and Asian samples (including one of two proposed risk haplotypes) being rare or absent in African samples. These results suggest a history of positive natural selection at the locus, resulting in significant geographic differences in polymorphism frequencies. The relationship of these differences to disease risk is discussed.
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