ArticleAmerican journal of human genetics2002
Genome scans provide evidence for low-HDL-C loci on chromosomes 8q23, 16q24.1-24.2, and 20q13.11 in Finnish families.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 108 citations in OpenAlex.
- Using machine learning to identify gene interaction networks associated with breast cancer.BMC cancer · 2022Article
- Genome Wide Association Study Identifies L3MBTL4 as a Novel Susceptibility Gene for Hypertension.Scientific reports · 2016Article
- The WWOX gene modulates high-density lipoprotein and lipid metabolism.Circulation. Cardiovascular genetics · 2014Article
- Exome sequencing identifies 2 rare variants for low high-density lipoprotein cholesterol in an extended family.Circulation. Cardiovascular genetics · 2012Article
- The genetics of familial combined hyperlipidaemia.Nature reviews. Endocrinology · 2012Review
- Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.PLoS genetics · 2012Article
- Association of a common LAMA5 variant with anthropometric and metabolic traits in an Italian cohort of healthy elderly subjects.Experimental gerontology · 2011Article
- WWOX gene is associated with HDL cholesterol and triglyceride levels.BMC medical genetics · 2010Article
- Effect of HDL composition and particle size on the resistance of HDL to the oxidation.Lipids in health and disease · 2010Article
- Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.PLoS genetics · 2010Article
- A genome-wide linkage scan identifies multiple quantitative trait loci for HDL-cholesterol levels in families with premature CAD and MI.Journal of lipid research · 2010Article
- Genome scan for loci regulating HDL cholesterol levels in Finnish extended pedigrees with early coronary heart disease.European journal of human genetics : EJHG · 2010Article
- Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.European journal of human genetics : EJHG · 2010Article
- A nonsynonymous SNP within PCDH15 is associated with lipid traits in familial combined hyperlipidemia.Human genetics · 2010Article
- OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism.Journal of molecular medicine (Berlin, Germany) · 2009Article
- Admixture mapping of quantitative trait loci for blood lipids in African-Americans.Human molecular genetics · 2009Article
- WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.American journal of human genetics · 2008Article
- Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia.Arteriosclerosis, thrombosis, and vascular biology · 2008Article
- Genetic variation and atherosclerosis.Current genomics · 2008Article
- TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia.Diabetologia · 2008Article
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed a genomewide scan for genes that predispose to low serum HDL cholesterol (HDL-C) in 25 well-defined Finnish families that were ascertained for familial low HDL-C and premature coronary heart disease. The potential loci for low HDL-C that were identified initially were tested in an independent sample group of 29 Finnish families that were ascertained for familial combined hyperlipidemia (FCHL), expressing low HDL-C as one component trait. The data from the previous genome scan were also reanalyzed for this trait. We found evidence for linkage between the low-HDL-C trait and three loci, in a pooled data analysis of families with low HDL-C and FCHL. The strongest statistical evidence was obtained at a locus on chromosome 8q23, with a two-point LOD score of 4.7 under a recessive mode of inheritance and a multipoint LOD score of 3.3. Evidence for linkage also emerged for loci on chromosomes 16q24.1-24.2 and 20q13.11, the latter representing a recently characterized region for type 2 diabetes. Besides these three loci, loci on chromosomes 2p and 3p showed linkage in the families with low HDL-C and a locus on 2ptel in the families with FCHL.
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