ArticleProceedings of the National Academy of Sciences of the United States of America2002
Ion channel gating: a first-passage time analysis of the Kramers type.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Information Entropy Metrics to Address the Complexity of Cooperative Gating of Ion Channels.Entropy (Basel, Switzerland) · 2026Article
- Beta-Barrel Channel Response to High Electric Fields: Functional Gating or Reversible Denaturation?International journal of molecular sciences · 2023Article
- Sensing Magnetic Fields with Magnetosensitive Ion Channels.Sensors (Basel, Switzerland) · 2018Article
- Power-Law Dynamics of Membrane Conductances Increase Spiking Diversity in a Hodgkin-Huxley Model.PLoS computational biology · 2016Article
- A Microscopic Capacitor Model of Voltage Coupling in Membrane Proteins: Gating Charge Fluctuations in Ci-VSD.The journal of physical chemistry. B · 2016Article
- Nonlinear and Stochastic Dynamics in the Heart.Physics reports · 2014Article
- Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A phase transition in the first passage of a Brownian process through a fluctuating boundary with implications for neural coding.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Gating of maxi channels observed from pseudo-phase portraits.American journal of physiology. Cell physiology · 2013Article
- On the simple random-walk models of ion-channel gate dynamics reflecting long-term memory.European biophysics journal : EBJ · 2012Article
- Fractal symmetry of protein interior: what have we learned?Cellular and molecular life sciences : CMLS · 2011Review
- A permeation theory for single-file ion channels: one- and two-step models.The Journal of chemical physics · 2011Article
- Slowing the translocation of double-stranded DNA using a nanopore smaller than the double helix.Nanotechnology · 2010Article
- Rate theories for biologists.Quarterly reviews of biophysics · 2010Review
- Principles of conduction and hydrophobic gating in K+ channels.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Fractals in the nervous system: conceptual implications for theoretical neuroscience.Frontiers in physiology · 2010Article
- Analyzing the forces binding a restriction endonuclease to DNA using a synthetic nanopore.Nucleic acids research · 2009Article
- Nanoelectromechanics of methylated DNA in a synthetic nanopore.Biophysical journal · 2009Article
- History-dependent multiple-time-scale dynamics in a single-neuron model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The opening rate of voltage-gated potassium ion channels exhibits a characteristic knee-like turnover where the common exponential voltage dependence changes suddenly into a linear one. An explanation of this puzzling crossover is put forward in terms of a stochastic first passage time analysis. The theory predicts that the exponential voltage dependence correlates with the exponential distribution of closed residence times. This feature occurs at large negative voltages when the channel is predominantly closed. In contrast, the linear part of voltage dependence emerges together with a nonexponential distribution of closed dwelling times with increasing voltage, yielding a large opening rate. Depending on the parameter set, the closed-time distribution displays a power law behavior that extends over several decades.
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