ArticleThe American journal of pathology2002
Chromosomal imbalances in choroid plexus tumors.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 110 citations in OpenAlex.
- Comprehensive multiomics analysis reveals distinct differences between pediatric choroid plexus papilloma and carcinoma.Acta neuropathologica communications · 2024Article
- The composition of choroid plexus tumor research: a bibliometric analysis of the 100 most impactful studies to date.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- A case report of hydrocephalus due to diffuse villous hyperplasia of the choroid plexus: surgical treatment by combination a flexible videoscope with a rigid endoscope.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Tumors of Choroid Plexus and Other Ventricular Tumors.Advances in experimental medicine and biology · 2023Article
- Congenital hydrocephalus in a trisomy 9p gained child: a case report.Journal of medical case reports · 2022Article
- Choroid plexus carcinoma in two siblings, with a novel genetic mutation in TP53 - A case report and review of literature.Surgical neurology international · 2022Article
- Moderate-to-strong expression of FGFR3 and TP53 alterations in a subpopulation of choroid plexus tumors.Histology and histopathology · 2020Article
- Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors.Journal of neuro-oncology · 2020Review
- Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma.Cancer research · 2019Article
- 9p24 triplication in syndromic hydrocephalus with diffuse villous hyperplasia of the choroid plexus.Cold Spring Harbor molecular case studies · 2018Article
- A new genetically engineered mouse model of choroid plexus carcinoma.Biochemical and biophysical research communications · 2018Article
- Molecular Guided Therapy Provides Sustained Clinical Response in Refractory Choroid Plexus Carcinoma.Frontiers in pharmacology · 2017Article
- Rare Primary Central Nervous System Tumors Encountered in Pediatrics.Journal of child neurology · 2016Review
- Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups.Neuro-oncology · 2016Article
- Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes.Cancer cell · 2015Article
- Surgical outcomes in choroid plexus papillomas: an institutional experience.Journal of neuro-oncology · 2013Article
- Choroid plexus papillomas: advances in molecular biology and understanding of tumorigenesis.Neuro-oncology · 2013Review
- Common molecular cytogenetic pathway in papillary tumors of the pineal region (PTPR).Brain pathology (Zurich, Switzerland) · 2011Article
- Melanotic choroid plexus carcinoma of the posterior fossa.Journal of clinical neurology (Seoul, Korea) · 2011Article
- A rare case of papillary carcinoma of choroids plexus: Its management and review of literature.Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology · 2011Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied 49 choroid plexus tumors by comparative genomic hybridization. Chromosomal imbalances were found in 32 of 34 choroid plexus papillomas and 15 of 15 choroid plexus carcinomas. Choroid plexus papillomas frequently showed +7q (65%), +5q (62%), +7p (59%), +5p (56%), +9p (50%), +9q (41%), +12p, +12q (38%), and +8q (35%) as well as -10q (56%), -10p, and -22q (47%); choroid plexus carcinomas mainly showed +12p, +12q, +20p (60%), +1, +4q, +20q (53%), +4p (47%), +8q, +14q (40%), +7q, +9p, +21 (33%) as well as -22q (73%), -5q (40%), -5p, and -18q (33%). Several chromosomal imbalance differences could be found that were characteristic for a tumor entity or age group. In choroid plexus papillomas +5q, +6q, +7q, +9q, +15q, +18q, and -21q were significantly more common whereas choroid plexus carcinomas were characterized by +1, +4q, +10, +14q, +20q, +21q, -5q, -9p, -11, -15q, and -18q. Among choroid plexus papillomas, children more often showed +8q, +14q, +12, and +20q; adults mainly presented with +5q, +6q, +15q, +18q, and -22q. Although the number of aberrations overall as well as of gains and losses on their own bore no significance on survival among choroid plexus tumors, a significantly longer survival among patients with choroid plexus carcinomas was associated with +9p and -10q. Our results show that aberrations differ between choroid plexus papillomas and choroid plexus carcinomas as well as between pediatric and adult choroid plexus papillomas, supporting the notion of different genetic pathways. Furthermore, gain of 9p and loss of 10q seem to be correlated with a more favorable prognosis in choroid plexus carcinomas.
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