ArticleThe American journal of pathology2002
Nitric oxide mediates apoptosis through formation of peroxynitrite and Fas/Fas-ligand interactions in experimental autoimmune uveitis.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 89 citations in OpenAlex.
- Macrophages in non-infectious uveitis: cell origin, disease stage, evidence provenance, and therapeutic maturity.Frontiers in immunology · 2026Review
- The Immunopathogenesis of uveitis.Frontiers in medicine · 2026Review
- Oral Administration of Piperine Ameliorates Experimental Autoimmune Uveitis.Inflammation · 2025Article
- Dual roles of myeloid-derived suppressor cells in various diseases: a review.Archives of pharmacal research · 2024Review
- Local Myeloid-Derived Suppressor Cells Impair Progression of Experimental Autoimmune Uveitis by Alleviating Oxidative Stress and Inflammation.Investigative ophthalmology & visual science · 2023Article
- Comparative Efficacy of Fish Meal Replacement With Enzymatically Treated Soybean Meal on Growth Performance, Immunity, Oxidative Capacity and Fecal Microbiota in Weaned Pigs.Frontiers in veterinary science · 2022Article
- TNF-α in Uveitis: From Bench to Clinic.Frontiers in pharmacology · 2021Review
- The Efficacy of Adalimumab as an Initial Treatment in Patients with Behçet's Retinal Vasculitis.Frontiers in pharmacology · 2021Article
- The Effects and Mechanism of Quercetin Dietary Supplementation in Streptozotocin-Induced Hyperglycemic Arbor Acre Broilers.Oxidative medicine and cellular longevity · 2020Article
- Folic acid deficiency and vision: a review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Review
- Propolis modulates NOS2/arginase-1 pathway in tropomyosin-induced experimental autoimmune uveitis.Inflammopharmacology · 2018Article
- Myeloid-derived suppressor cells and myeloid regulatory cells in cancer and autoimmune disorders.Experimental and therapeutic medicine · 2017Article
- Correlation of inducible nitric oxide synthase (iNOS) inhibition with TNF-α, caspase-1, FasL and TLR-3 in pathogenesis of rabies in mouse model.Virus genes · 2016Article
- Correlation between Fluorescein Angiographic Findings and Visual Acuity in Behçet Retinal Vasculitis.Yonsei medical journal · 2015Article
- Macrophages and Uveitis in Experimental Animal Models.Mediators of inflammation · 2015Review
- Role of myeloid-derived suppressor cells in autoimmune disease.World journal of immunology · 2014Article
- Role of the retinal vascular endothelial cell in ocular disease.Progress in retinal and eye research · 2013Review
- Interplay between innate and adaptive immunity in the development of non-infectious uveitis.Progress in retinal and eye research · 2012Review
- Nitric oxide potentiates TNF-α-induced neurotoxicity through suppression of NF-κB.Cellular and molecular neurobiology · 2012Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Conflicting reports have led to the description of nitric oxide as a "double-edged sword" in animal models of autoimmunity. In this study we show that tissue damage within the eye during experimental autoimmune uveoretinitis correlates with peroxynitrite formation in infiltrating monocytes/macrophages within the outer retina together with extensive photoreceptor apoptosis and apoptosis of Fas(+) T cells within the retina. Inducible nitric oxide synthase (NOS2) expression was primarily restricted to infiltrating monocytes/macrophages in the outer retina and photoreceptor rod outer segments (target tissue), but despite showing evidence of lipid peroxidation, myeloid cells remained resistant to apoptosis. The protective effect of the NOS inhibitor N(G)-nitro-L-arginine methyl ester could be attributed to dramatically reduced photoreceptor apoptosis, absence of nitrotyrosine formation, and reduced NOS2 protein expression. However, inhibition of NOS by N(G)-nitro-L-arginine methyl ester was accompanied by a sparing of CD3(+) and CD2(+) T cells despite continued expression of Fas and Fas ligand, thus compromising functional inactivation of T cells in the target tissue. These data suggests that in addition to contributing to tissue damage in the retina through generation of reactive oxygen species, nitric oxide also seems to be required for activation-induced cell death and elimination of T cells in the retina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.